37951-09-0

Basic information

• Product Name: Benzenemethanol, a-(1-methylethyl)-a-phenyl-
• CAS NO: 37951-09-0
• Molecular Formula: C16H18O
• Molecular Weight: 226.318
• Mol File: 37951-09-0.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(1-methylethyl)-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(1-methylethyl)-a-phenyl-(37951-09-0)
• EPA Substance Registry System: Benzenemethanol, a-(1-methylethyl)-a-phenyl-(37951-09-0)

Safety Data

• Hazardous Substances Data: 37951-09-0(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 591-51-5 phenyllithium 
• 75-26-3 isopropyl bromide 
• 611-70-1 phenyl isopropyl ketone 
• 60-29-7 diethyl ether 
• 79-31-2 isobutyric Acid 
• 547-63-7 Methyl isobutyrate 
• 100-58-3 phenylmagnesium bromide 
• 75-30-9 2-iodo-propane 
• 119-61-9 benzophenone 
• 60227-39-6 1,1-diphenyl-1,2-epoxy-2-methylpropane 
• 920-39-8 isopropylmagnesium bromide 
• 2973-10-6 diisopropyl sulfate 
• 1068-55-9 isopropylmagnesium chloride 

Downstream Products

• 98-82-8 Isopropylbenzene 
• 101-53-1 p-benzylphenol 
• 852058-18-5 4-Hydroxy-1-(2-methyl-1.1-diphenyl-propyl)-benzol 
• 38660-83-2 N-(2-methyl-1-phenyl-1-propylidene) aniline 
• 145909-49-5 α-(1-methylethyl)-N-phenyl-benzenemethanamine 
• 1016565-38-0 C₁₉H₂₃NO₂S 
• 60227-39-6 1,1-diphenyl-1,2-epoxy-2-methylpropane 
• 80743-47-1 2,2-diphenyl-3-methylbutanoic acid 
• 1634-11-3 1,1-diphenyl-2-methylpropane 
• 119-61-9 benzophenone 
• 13740-70-0 2-methyl-1,2-diphenyl-propan-1-one 
• 781-33-9 2-methyl-1,1-diphenylpropene 

Relevant articles and documents

Catalytic Functionalization of Styrenyl Epoxides via 2-Nickela(II)oxetanes

Low-valent nickel is shown to preferentially isomerize mono- or disubstituted epoxides into their corresponding aldehydes. Experiments with tetrasubstituted epoxides demonstrate that these reactions proceed via reactive 2-nickelaoxetane intermediates, and

A simple and efficient copper oxide-catalyzed Barbier-Grignard reaction of unactivated aryl or alkyl bromides with ester

An efficient one-pot route to synthesize tertiary alcohol compounds using Barbier-Grignard reaction of unactivated alkyl or aryl bromides with ester in THF at 65 C catalyzed by CuO has been developed and systematically investigated. A wide range of substituted tertiary alcohol compounds were obtained in good to high yields. The reaction is highly chemoselective. The mechanism involving the leaving group of R2O-group is discussed.

Added-metal-free catalytic nucleophilic addition of Grignard reagents to ketones

On the basis of the investigation of the combinational effect of quaternary ammonium salts and organic bases, an added-metal-free catalytic system for nucleophilic addition reactions of a variety of Grignard reagents to diverse ketones in THF solvent has been developed to produce tertiary alcohols in good to excellent yields. By using tetrabutylammonium chloride (NBu4Cl) as a catalyst and diglyme (DGDE) as an additive, this system strongly enhances the efficiency of addition at the expense of enolization and reduction. NBu 4Cl should help to shift the Schlenk equilibrium of Grignard reagents to the side of dimeric Grignard reagents to favor the additions of Grignard reagents to ketones via a favored six-membered transition state to form the desired tertiary alcohols, and DGDE should increase the nucleophilic reactivities of Grignard reagents by coordination. This catalytic system has been applied in the efficient synthesis of Citalopram, an effective U.S. FDA-approved antidepressant, and a recyclable version of this catalytic synthesis has also been devised.