37968-69-7

Basic information

• Product Name: Pyrimidine, 2-chloro-4-ethynyl- (9CI)
• Synonyms: Pyrimidine, 2-chloro-4-ethynyl- (9CI);2-Chloro-4-ethynylpyrimidine
• CAS NO: 37968-69-7
• Molecular Formula: C₆H₃ClN₂
• Molecular Weight: 138.55442
• Product Categories: PYRIMIDINE
• Mol File: 37968-69-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139-141 °C
• Boiling Point: 272.1±13.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: -2.67±0.20(Predicted)
• CAS DataBase Reference: Pyrimidine, 2-chloro-4-ethynyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-chloro-4-ethynyl- (9CI)(37968-69-7)
• EPA Substance Registry System: Pyrimidine, 2-chloro-4-ethynyl- (9CI)(37968-69-7)

Safety Data

• Hazardous Substances Data: 37968-69-7(Hazardous Substances Data)

Usage

Description

Pyrimidine, 2-chloro-4-ethynyl(9CI) is a chemical compound with the molecular formula C6H3ClN2. It is a derivative of pyrimidine, a heterocyclic organic compound found in DNA and RNA. The 2-chloro-4-ethynylsubstitution on the pyrimidine ring makes this compound a potential candidate for use in pharmaceutical research and drug development.

Uses

Used in Pharmaceutical Research and Drug Development:
Pyrimidine, 2-chloro-4-ethynyl(9CI) is used as a building block in the synthesis of various bioactive compounds and pharmaceuticals. Its unique structure allows for the development of new drugs for various medical conditions.
Used in the Synthesis of Bioactive Compounds:
Pyrimidine, 2-chloro-4-ethynyl(9CI) is used as a key intermediate in the synthesis of bioactive compounds, which can have potential applications in the treatment of various diseases and disorders.
It should be noted that due to its potential hazards, Pyrimidine, 2-chloro-4-ethynyl(9CI) should be handled and used with caution.

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 74-86-2 acetylene 
• 37972-23-9 2-chloro-4-((trimethylsilyl)ethynyl)pyrimidine 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 945016-63-7 3-(2-chloro-pyrimidin-4-yl)-1H-indole 
• 1214264-48-8 3-(2-chloropyrimidin-4-yl)-7-nitro-1H-indole 

Relevant articles and documents

Optimization of a series of potent, selective and orally bioavailable SYK inhibitors

Spleen tyrosine kinase (SYK) is a non-receptor cytosolic kinase. Due to its pivotal role in B cell receptor and Fc-receptor signaling, inhibition of SYK has been targeted in a variety of disease areas. Herein, we report the optimization of a series of potent and selective SYK inhibitors, focusing on improving metabolic stability, pharmacokinetics and hERG inhibition. As a result, we identified 30, which exhibited no hERG activity but unfortunately was poorly absorbed in rats and mice. We also identified a SYK chemical probe, 17, which exhibits excellent potency at SYK, and an adequate rodent PK profile to support in vivo efficacy/PD studies.

One-pot synthesis of meridianins and meridianin analogues via indolization of nitrosoarenes

Meridianins, marine alkaloids known as kinase inhibitors with an indole skeleton, and meridianin analogues were produced regioselectively and in moderate to good yields by thermal annulation of nitrosoarenes with 2-amino-4-ethynylpyrimidine and 2-chloro-4-ethynylpyrimidine, respectively, through a novel and atom-economical indolization process.