37972-69-3

Basic information

• Product Name: 6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE
• Synonyms: 6-Hydroxy-3-pyridazinecarboxylic acid monohydrate;6-hydroxy-pyridazine-3-carboxylic acid;6-Hydroxy-3-pyridazinecarboxylic acid;2,3-DIHYDRO-3-OXOPYRIDAZIN-6-CARBOXYLIC ACID, MONOHYDRATE;6-Oxo-1,6-dihydropyridazine-3-carboxylic acid;3-hydroxypyridazine-6-car...;6-oxo-1,6-dihydropyridazine-3-carboxylic acid(SALTDATA: FREE);4-hydroxypyriMidine-2-carboxylic acid
• CAS NO: 37972-69-3
• Molecular Formula: C₅H₄N₂O₃
• Molecular Weight: 158.11214
• EINECS: 220-753-0
• Product Categories: Pyridazine series;pyridazine
• Mol File: 37972-69-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 246 °C
• Boiling Point: 518.5 °C at 760 mmHg
• Flash Point: 267.4 °C
• Appearance: /
• Density: 1.63 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.86±0.20(Predicted)
• CAS DataBase Reference: 6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE(37972-69-3)
• EPA Substance Registry System: 6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE(37972-69-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 37972-69-3(Hazardous Substances Data)

Usage

Description

6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE is a carboxylic acid derivative characterized by its unique chemical structure, which features a hydroxyl group attached to a pyridazine ring and a carboxylic acid group. 6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE is known for its potential applications in various fields due to its versatile chemical properties.

Uses

Used in Organic Synthesis:
6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE is used as an intermediate in organic synthesis for the development of various chemical compounds. Its unique structure allows it to serve as a building block for the creation of more complex molecules, which can be utilized in different industries such as pharmaceuticals, agrochemicals, and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE is used as a key intermediate for the synthesis of various drug candidates. Its chemical properties make it a valuable component in the development of new medications, particularly those targeting specific biological pathways or receptors.
Used in Agrochemical Industry:
6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE is also utilized in the agrochemical industry as an intermediate for the synthesis of pesticides, herbicides, and other crop protection agents. Its unique structure allows for the development of novel compounds with improved efficacy and selectivity, contributing to more effective and environmentally friendly agricultural practices.
Used in Materials Science:
In the field of materials science, 6-HYDROXY-3-PYRIDAZINECARBOXYLIC ACID MONOHYDRATE can be used as a component in the development of advanced materials with specific properties. Its chemical structure can be manipulated to create materials with tailored characteristics, such as improved mechanical strength, thermal stability, or chemical resistance, for various applications in industries like electronics, automotive, and aerospace.

InChI:InChI=1/C5H4N2O3/c8-4-2-1-3(5(9)10)6-7-4/h1-2H,(H,7,8)(H,9,10)/p-1

Upstream product

• 13327-27-0 6-Methylpyridazin-3(2H)-on 
• 1121-79-5 3-chloro-6-methylpyridazine 
• 27372-38-9 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid 
• 328-50-7 α-ketoglutaric acid 
• 13327-27-0 3-hydroxy-6-methylpyridazine 
• 27372-38-9 3-Hydroxy-6-carboxy-4.5-dihydro-pyridazin 

Downstream Products

• 5096-73-1 6-chloro-pyridazine-3-carboxylic acid 
• 63001-31-0 6-hydroxy-3-pyridazinecarboxylic acid ethyl ester 
• 1025446-21-2 2-(6-oxo-1,6-dihydropyridazin-3-yl)imidazo[4,5-c]pyridin-4-one 
• 57658-96-5 6-hydroxypyridazine-3-carbonyl chloride 
• 944808-73-5 3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-chloropyridazine 
• 944808-71-3 6-(3-benzyl-1,2,4-oxadiazol-5-yl)pyridazin-3-ol 
• 75680-92-1 6-chloro-3-pyridazinecarboxylic acid ethyl ester 
• 6531-04-0 6-chloro-pyridazine-3-carbonyl chloride 
• 63001-30-9 methyl 6‐oxo‐1,6‐dihydropyridazine‐3‐carboxylate 

Relevant articles and documents

Synthesis of 3-chloropyridazine-6-carboxylic acid hydrazide and selective hydrazinolysis of 3,6-substituted pyridazines

3-Chloropyridazine-6-carboxylic acid hydrazide (5) was synthesized by employing hydrazine monohydrate and methyl levalinate as starting materials through five steps, including hydrazinolysis. Selective hydrazinolysis of 3,6-substituted pyridazines was investigated.

METHODS OF MANUFACTURING A BIFUNCTIONAL COMPOUND, ULTRAPURE FORMS OF THE BIFUNCTIONAL COMPOUND, AND DOSAGE FORMS COMPRISING THE SAME

The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A: The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies

Herein, we described the design and synthesis of a series of pyridazine-3-carboxamides to be CB2-selective agonists via a combination of scaffold hopping and bioisosterism strategies. The compounds were subjected to assessment of their potential activities through calcium mobilization assays. Among the tested derivatives, more than half of these compounds exhibited moderate to potent CB2 agonist activity. Six compounds showed EC50 values below 35 nM, and several derivatives also exhibited significantly enhanced potency and high selectivity at the CB2 receptor over the CB1 receptor. Specifically, compound 26 showed the highest CB2 agonist activity (EC50 = 3.665 ± 0.553 nM) and remarkable selectivity (Selectivity Index > 2729) against CB1. In addition, logPs of some representative compounds were measured to display significantly decreased values in comparison with GW842166X. Furthermore, docking simulations were conducted to explain the interaction mode of this series.

TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.