3801-89-6

Basic information

• Product Name: 1-(3-FLUOROPHENYL)PIPERAZINE
• Synonyms: 1-(3-FLUOROPHENYL)PIPERAZINE;1-(3-Fluorophenyl)piperazine 97%;1-(3-Fluorophenyl)piperazine97%;1-(3-Fluorophenyl)piperazine ,98%;Piperazine,1-(3-fluorophenyl)-
• CAS NO: 3801-89-6
• Molecular Formula: C10H13FN2
• Molecular Weight: 180.22
• EINECS: 223-271-9
• Product Categories: piperazines
• Mol File: 3801-89-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 88-91°C 0,2mm
• Flash Point: 136.242 °C
• Appearance: /
• Density: 1.113 g/cm³
• PKA: 8.85±0.10(Predicted)
• CAS DataBase Reference: 1-(3-FLUOROPHENYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-FLUOROPHENYL)PIPERAZINE(3801-89-6)
• EPA Substance Registry System: 1-(3-FLUOROPHENYL)PIPERAZINE(3801-89-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-52-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 3801-89-6(Hazardous Substances Data)

Usage

Description

1-(3-Fluorophenyl)piperazine is a chemical compound belonging to the Piperazine (P480100) family of derivatives. It is characterized by the presence of a fluorophenyl group attached to the piperazine molecule, which may contribute to its unique properties and potential applications.

Uses

Used in Pharmaceutical Industry:
1-(3-Fluorophenyl)piperazine is used as an active pharmaceutical ingredient for the development of medications targeting various medical conditions. Its specific application reason is due to its structural properties that may allow it to interact with specific biological targets or receptors in the body.
Used in Veterinary Medicine:
1-(3-Fluorophenyl)piperazine is used as an anthelmintic agent for the treatment of parasitic worms in animals. Its application reason is based on its ability to effectively target and eliminate parasites, improving the health and well-being of the animals being treated.

InChI:InChI=1/C10H13FN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2

Upstream product

• 372-19-0 meta-fluoroaniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 1073-06-9 3-fluorobromobenzene 
• 951626-85-0 tert-butyl 4-(3-fluorophenyl)piperazine-1-carboxylate 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 110-85-0 piperazine 
• 625-98-9 3-chlorofluorobenzene 

Downstream Products

• 72222-97-0 3-[4-(3-fluoro-phenyl)-piperazin-1-yl]-2H-benzo[1,4]oxazine 
• 57962-06-8 2-{2-[4-(3-fluoro-phenyl)-piperazin-1-yl]-ethyl}-quinoline 
• 78069-82-6 1-(3-Fluoro-phenyl)-4-(3-nitro-pyridin-4-yl)-piperazine 
• 137965-89-0 1-{5-[4-(3-Fluoro-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-pyrrolidin-2-one 
• 130933-63-0 4-[4-(3-Fluoro-phenyl)-piperazin-1-yl]-N-(4aS,5S,11aS)-1,2,3,4,4a,5,11,11a-octahydro-10-thia-dibenzo[a,d]cyclohepten-5-yl-butyramide 
• 103247-41-2 2-[4-(3-Fluoro-phenyl)-piperazin-1-yl]-N-(7-hydroxy-2,2,4,6-tetramethyl-indan-1-yl)-acetamide 
• 127625-56-3 2-<3-<4-(3-fluorophenyl)-1-piperazinyl>propyl>-2H-naphth<1,8-cd>isothiazole 1,1-dioxide 
• 139331-47-8 2-{3-[4-(3-fluorophenyl)-1-piperazinyl]propyl}-5-methyl-2H-1,4-benzothiazin-3(4H)-one.dihydrochloride 
• 112249-43-1 2-{3-[4-(3-fluorophenyl)-1-piperazinyl]propyl}-6,7,8,9-tetrahydro-2H-naphtho[2,3-b][1,4]oxazin-3(4H)-one 
• 83472-20-2 1-[4-(3-Fluoro-phenyl)-piperazin-1-yl]-3-(3,7,7-trimethyl-5,9-dihydro-6,8-dioxa-2-aza-benzocyclohepten-4-yloxy)-propan-2-ol 
• 103073-19-4 2-(2-{3-[4-(3-Fluoro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-thiazolidine-3-carboxylic acid methylamide 
• 72566-46-2 7-{3-[4-(3-fluoro-phenyl)-piperazin-1-yl]-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 117518-25-9 N-[2-(dimethylamino)ethyl]-4-(3-fluorophenyl)-1-piperazinecarboxamide 
• 218940-66-0 N-(3-fluorophenyl)-4-methylpiperazine 

Relevant articles and documents

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors

A high-throughput screening (HTS) campaign identified a class of heteroaryl piperazines with excellent baseline affinity and selectivity for phosphoinositide 3-kinase δ (PI3Kδ) over closely related isoforms. Rapid evaluation and optimization of structure-activity relationships (SAR) for this class, leveraging the modular nature of this scaffold, facilitated development of this hit class into a series of potent and selective inhibitors of PI3Kδ. This effort culminated in the identification of 29, which displayed excellent potency in enzyme and cell-based assays, as well as favorable pharmacokinetic and off-target profiles.

MONOACYLGLYCEROL LIPASE INHIBITORS

Provided are compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof: Also provided are compositions comprising compounds of formula (I). The compounds and compositions are also provided for use as medicaments, for example as medicaments useful in the treatment of a condition modulated by monoacylglycerol lipase (MAGL). Also provided are the use of compounds and compositions for the inhibition of monoacylglycerol lipase (MAGL).

Identification of novel GLUT inhibitors

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.