38010-31-0Relevant articles and documents
One-pot copper-catalyzed three-component reaction: A modular approach to functionalized 2-quinolones
Kim, Ah Reum,Lim, Hee Nam
, p. 7855 - 7866 (2020/03/11)
A copper-catalyzed three-component annulation for the synthesis of functionalized 2-quinolones was developed. Three reactions including an SN2, a Knoevenagel, and finally C-N bond formation are involved in the designed cascade reaction using 2-bromoacylarenes, 2-iodoacetamide, and nucleophiles as the three components. A new catalytic system was discovered during the study and this modular approach is highly efficient to access functionalized 2-quinolone derivatives, compatible with a broad range of functional groups, scalable, and step-economic. Further derivatization of the obtained product demonstrates the synthetic utility of this method.
α-Phenylsulfonyl-N-arylacetamides (α-phenylsulfonylacetanilides): 1H, 13C and 15N NMR spectral characterization
Kolehmainen, Erkki,Janota, Henryk,Gawinecki, Ryszard,Laihia, Katri,Kauppinen, Reijo
, p. 384 - 385 (2007/10/03)
1H and 13C NMR chemical shift assignments for 11 α-phenylsulfonylacetanilides and 15N NMR chemical shifts for four representative congeners are reported. The 1H and 13C chemical shift assignments are based on DQF COSY and PFG 1H, 13C HMQC/HMBC experiments. The 15N NMR chemical shifts were determined by PFG 1H, 15N HMBC experiments. The correlation analyses with Hammett-type substituent constants gave a significant result with δ(C-1) in the aniline ring. Copyright