38018-27-8 Usage
Description
(1-but-3-ynyl)pyrrolidine-2,5-dione, also known as acetylenedicarboximide, is a chemical compound with the molecular formula C7H7NO2. It is a derivative of pyrrolidine-2,5-dione, also known as succinimide, and contains an alkyne group at the 3rd position of the butyl chain. (1-but-3-ynyl)pyrrolidine-2,5-dione is characterized by its unique reactivity and serves as a versatile building block in the synthesis of pharmaceuticals and agrochemicals.
Uses
Used in Organic Synthesis:
(1-but-3-ynyl)pyrrolidine-2,5-dione is used as a versatile intermediate in organic synthesis for its ability to undergo various reactions, including addition, substitution, and condensation. This allows for the formation of a wide range of organic compounds.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (1-but-3-ynyl)pyrrolidine-2,5-dione is used as a key building block for the synthesis of various pharmaceuticals. Its unique reactivity contributes to the development of new and innovative drugs.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical industry, (1-but-3-ynyl)pyrrolidine-2,5-dione is utilized as an important intermediate for the synthesis of agrochemicals, such as pesticides and herbicides, due to its potential to form a diverse array of compounds.
It is crucial to handle (1-but-3-ynyl)pyrrolidine-2,5-dione with care, as it can be hazardous if not properly used and stored. Proper safety measures and storage conditions are essential to ensure the safe utilization of this compound in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 38018-27-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,0,1 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38018-27:
(7*3)+(6*8)+(5*0)+(4*1)+(3*8)+(2*2)+(1*7)=108
108 % 10 = 8
So 38018-27-8 is a valid CAS Registry Number.
38018-27-8Relevant articles and documents
Synthesis of succinimidoalkylbenzaldehyde analogues: Potential bifunctional linkers for bioconjugation
Crosby, Ian T.,Pietersz, Geoffrey A.,Ripper, Justin A.
, p. 138 - 143 (2008/04/04)
A series of novel 4-substituted benzaldehydes containing a succinimide moiety were synthesized as potential bifunctional linkers for the purpose of binding therapeutic drugs to antibodies raised against cancer cells. These potential benzaldehyde linkers varied in the nature of the para functionality so as to provide a range of potential acid labilities. Synthesis of the linkers involved a Williamson ether formation to make the ether linker 1, a Sonagoshira palladium-catalyzed coupling to synthesize the skeleton of the alkyl linker 2, and formation of an amide bond directly from a methyl ester gave the 4-substituted amide linker 3. As an example of the type of acetal that can be produced using these linkers, uridine was used as an analogue of the cytotoxic compound 5-fluorouridine to give the cyclic acetals 19?21. CSIRO 2008.
Model studies for damage to nucleic acids mediated by thiyl radicals
Griffiths,Murphy
, p. 5543 - 5556 (2007/10/02)
The ability of phenylthiovinyl radicals to abstract hydrogen from appropriately substituted carbon atoms has been studied as a model for the reactions of the deoxyribose units of DNA with similar radicals in two.
SILA-PUMMERER REARRANGEMENTS AT SP2-HYBRIDIZED CARBON
Hart, David J.,Tsai, Yeun-Min
, p. 4387 - 4390 (2007/10/02)
α-Trimethylsilylvinyl sulfoxides undergo sila-Pummerer rearrangements upon warming in benzene.Alkynes, vinylsulfoxides, and ketene S,O-acetals are obtained as products.
