380335-36-4Relevant articles and documents
Solubility and thermodynamic analysis of N′-(1-(N-(methyl) benzylaminomethyl)-2-oxoindolin-3-ylidene)-2-(benzyloxy) benzohydrazide in different neat solvents at different temperatures
Shakeel, Faiyaz,Haq, Nazrul,Radwan, Awwad A.,Alanazi, Fars K.,Alsarra, Ibrahim A.
, p. 108 - 112 (2016)
The present study was undertaken to determine the solubilities of newly synthesized anticancer compound N′-(1-(N-(methyl) benzylaminomethyl)-2-oxoindolin-3-ylidene)-2-(benzyloxy) benzohydrazide (NMBOBB) in nine different neat solvents including water, isopropanol (IPA), ethanol, ethylene glycol (EG), 1.2-propanediol (PG), 1-butanol, 2-butanol, polyethylene glycol-400 (PEG-400) and Transcutol (diethylene glycol monoethyl ether) at T = 298.15 K to 318.15 K and p = 0.1 MPa. Experimental solubility data of NMBOBB was fitted with Apelblat and ideal models. The mole fraction solubility of NMBOBB was recorded highest in PEG-400 (1.14 × 10- 2 at T = 318.15 K) followed by Transcutol (7.14 × 10- 3 at T = 318.15 K), 2-butanol (1.45 × 10- 3 at T = 318.15 K), 1-butanol (1.38 × 10- 3 at T = 318.15 K), ethanol (9.69 × 10- 4 at T = 318.15 K), PG (9.52 × 10- 4 at T = 318.15 K), IPA (9.41 × 10- 4 at T = 318.15 K), EG (8.09 × 10- 4 at T = 318.15 K) and water (3.00 × 10- 6 at T = 318.15 K). The highest solubility of NMBOBB in PEG-400 was possible due to lower polarity and higher molar mass of PEG-400. The dissolution behavior of NMBOBB was observed as an endothermic, spontaneous and an entropy-driven due to positive values of standard enthalpies, Gibbs free energies and entropies in all nine neat solvents investigated. The results of this work would be helpful in purification, recrystallization and dosage form design of NMBOBB.
Recyclable CuO nanoparticles-catalyzed synthesis of novel-2,5-disubstituted 1,3,4-oxadiazoles as antiproliferative, antibacterial, and antifungal agents
Murty,Penthala, Raju,Buddana, Sudheer Kumar,Prakasham,Das, Pompi,Polepalli, Sowjanya,Jain,Bojja, Sreedhar
, p. 4579 - 4594 (2016/02/20)
A series of new 2,5-disubstituted 1,3,4-oxadiazoles have been conveniently synthesized through an oxidative C-O coupling by direct C-H bond activation of N-aroyl-N-arylidinehydrazines using a catalytic quantity of CuO nanoparticles. Twenty compounds have been synthesized in good to excellent yields (75-90 %). All the synthesized compounds were evaluated for their in vitro antiproliferative, antibacterial, and antifungal activity. Compounds 8d and 10d are more promising antiproliferative agents with IC50 value of 3.66 and 3.89 μM in MCF-7 cell line, and compounds 8a and 10a were showed more potent antifungal activity than standard drug.
Synthesis and anticonvulsant activity of new 2-substituted-5-(2- benzyloxyphenyl)-1,3,4-oxadiazoles
Zarghi, Afshin,Tabatabai, Sayyed A.,Faizi, Mehrdad,Ahadian, Avideh,Navabi, Parisa,Zanganeh, Vahideh,Shafiee, Abbas
, p. 1863 - 1865 (2007/10/03)
A series of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles have been synthesized and evaluated as anticonvulsant agents. Compound 4b shows considerable anticonvulsant activity both in PTZ and MES models. It seems this effect is mediated through benzodiazepine receptors mechanism.
