380414-67-5

Basic information

• Product Name: Ethanone, 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[[(1S)-2-hydroxy-1-phenyleth yl]amino]-
• CAS NO: 380414-67-5
• Molecular Formula: C20H23NO4
• Molecular Weight: 341.407
• Mol File: 380414-67-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[[(1S)-2-hydroxy-1-phenyleth yl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[[(1S)-2-hydroxy-1-phenyleth yl]amino]-(380414-67-5)
• EPA Substance Registry System: Ethanone, 1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-[[(1S)-2-hydroxy-1-phenyleth yl]amino]-(380414-67-5)

Safety Data

• Hazardous Substances Data: 380414-67-5(Hazardous Substances Data)

Upstream product

• 20989-17-7 (2S)-2-phenylglycinol 
• 102293-80-1 2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone 
• 62932-94-9 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)-phenyl]ethanone 
• 99-93-4 4-Hydroxyacetophenone 
• 24085-07-2 3'-acetoxymethyl-4'-acetoxy-2-bromoacetophenone 
• 24085-06-1 4'-acetoxy-3'-(acetoxymethyl)acetophenone 

Downstream Products

• 380414-68-6 (1R,1'S)-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-(2-hydroxy-1-phenyl-ethylamino)-ethanol 
• 135271-47-5 (R)-(-)-salmeterol 
• 590410-69-8 (R)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-(6-(4-phenylbutoxy)hexylamino)ethanol 
• 500317-72-6 (4S)-3-[2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxoethyl]-4-phenyl-1,3-oxazolidin-2-one 

Relevant articles and documents

Synthesis of the β2 Agonist (R)-Salmeterol Using a Sequence of Supported Reagents and Scavenging Agents

(Matrix Presented) The enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxiliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.

A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride-calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative

A short and efficient enantioselective route to (R)-salmeterol involving asymmetric reduction of a phenylglycinyl ketone derivative followed by reductive amination of the resulting amino alcohol and hydrogenolysis is described.