38046-98-9

Basic information

• Product Name: 3-CHLORO-1-(4-METHYLPHENYL)PYRROLIDINE-2,5-DIONE
• Synonyms: 3-CHLORO-1-(4-METHYLPHENYL)PYRROLIDINE-2,5-DIONE;AKOS BBS-00002201;ART-CHEM-BB B023324
• CAS NO: 38046-98-9
• Molecular Formula: C₁₁H₁₀ClNO₂
• Molecular Weight: 223.66
• Mol File: 38046-98-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-CHLORO-1-(4-METHYLPHENYL)PYRROLIDINE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1-(4-METHYLPHENYL)PYRROLIDINE-2,5-DIONE(38046-98-9)
• EPA Substance Registry System: 3-CHLORO-1-(4-METHYLPHENYL)PYRROLIDINE-2,5-DIONE(38046-98-9)

Safety Data

• Hazardous Substances Data: 38046-98-9(Hazardous Substances Data)

Upstream product

• 111141-29-8 N,N'-di-p-tolyl-malamide 
• 24870-11-9 4-methylmaleanilic acid 
• 106-49-0 p-toluidine 

Downstream Products

• 1631-28-3 N-p-tolylphenylmaleimide 
• 2314-79-6 N-(p-tolyl)succinimide 

Relevant articles and documents

Substituent effects on the regioselectivity of maleamic acid formation and hydrogen chloride addition to N-aryl maleimides

Itaconic anhydride reacts with aryl amines to give a substituent controlled equilibrium mixture of regioisomeric (Z)-2-methyl- and (Z)-3-methyl-4-oxo-4- (arylamino)but-2-enoic acids. Electron-donating groups favor nucleophilic attack on C-5 carbonyl, while the presence of electron-withdrawing groups enhances the bias for attack on C-2 carbonyl. The treatment of (Z)-2-methyl- and (Z)-3-methyl-4-oxo-4-(arylamino)but-2-enoic acids with SOCl2-Et 3N in THF provided the corresponding maleimides in high yields while under the same conditions the maleic anhydride aryl amine addition products gave predominately the corresponding 3-chloro-1-arylpyrrolidine-2,5-diones and maleimides in substituent dependent ratio. TUeBITAK, 2012.