3805-23-0 Usage
Description
5-Methylthiazolidine-2,4-dione is a thiazolidine-2,4-dione derivative with the molecular formula C5H7NO2S. It is a white to off-white crystalline powder that is soluble in water and insoluble in organic solvents. This chemical compound serves as a precursor to the antidiabetic agent pioglitazone and is used as a building block in the synthesis of pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
5-Methylthiazolidine-2,4-dione is used as a precursor for the synthesis of pioglitazone, an antidiabetic agent. It plays a crucial role in the development of medications for the treatment of diabetes and other metabolic disorders.
Used in Chemical Synthesis:
5-Methylthiazolidine-2,4-dione is used as a building block in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for a range of chemical reactions, enabling the production of derivatives with enhanced or specific properties for different applications.
Used in Research and Development:
5-Methylthiazolidine-2,4-dione has potential applications in research and development for the discovery of new therapeutic agents. Its ability to undergo chemical modifications makes it a valuable tool for exploring novel compounds with potential benefits in treating various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 3805-23-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,0 and 5 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3805-23:
(6*3)+(5*8)+(4*0)+(3*5)+(2*2)+(1*3)=80
80 % 10 = 0
So 3805-23-0 is a valid CAS Registry Number.
3805-23-0Relevant articles and documents
Synthesis and antibacterial activity of 5-aryl-2- [(α-chloro-α-phenylacetyl/α- bromopropionyl)amino]-1,3,4-oxadiazoles and 2-[(5-aryl-1 ,3,4-oxadiazol-2-yl)imino]-5-phenyl/methyl-4-thiazolidinones
Ates, Oeznur,Kocabalkanlr, Ayse,Sanis, Guelten Oetuek,Ekinci, Ahmet C.,Vidin, Aylin
, p. 1134 - 1138 (2007/10/03)
Reaction of 5-aryl-2-amino-1,3,4-oxadiazoles (B(I-VI)), obtained by the oxydative cyclization of aromatic aldehyde semicarbazones (A(I-VI)), with α-chloro-α-phenylacetyl chloride and a-bromopropionyl bromide yielded 5-aryl-2-[(α-chloro-α-phenylacetyl)amino]-1,3,4-oxadiazoles (Ia-VIa) and 5-aryl-2-[(α-bromopropionyl)amino]-1, 3,4-oxadiazoles (VIIa-XIIa), respectively. Furthermore, Ia-XIIa were refluxed with ammonium thiocyanate to give 5-phenyl/methyl-2-[(5-aryl-1,3,4-oxadiazol-2-yl)imino]-4-thiazolidinones (It-XIIt). All compounds were tested for antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. They were all found to possess significant activity against S. aureus with MIC values ranging from 0.24 to 125 μg/ml. LD50 of compounds chosen as prototypes are estimated.
