3805-37-6 Usage
Description
[(2R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxy-oxolan-2-yl]methoxyphosphonic acid, also known as cidofovir, is a nucleotide analog antiviral medication with potent and specific activity against a variety of DNA viruses. It possesses a unique structure that allows it to inhibit viral DNA polymerase, thereby preventing the replication of the virus. Cidofovir is administered intravenously and is phosphorylated within the host cell to its active form, making it a valuable option for the treatment of some serious viral infections.
Uses
Used in Antiviral Applications:
Cidofovir is used as an antiviral agent for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It modulates the viral replication process by inhibiting viral DNA polymerase, exerting inhibitory effects on the growth and progression of the virus.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, cidofovir is used as a potent and specific antiviral agent with activity against a variety of DNA viruses. Its unique mechanism of action and effectiveness against serious viral infections make it a valuable option for the development of new antiviral medications and treatment strategies.
Used in AIDS Treatment:
Cidofovir is used in the treatment of AIDS patients suffering from cytomegalovirus (CMV) retinitis. Its antiviral properties help in managing the symptoms and progression of the disease, improving the quality of life for these patients.
However, it is important to note that cidofovir can cause nephrotoxicity, and its use should be approached with caution in patients with renal impairment. This highlights the need for further research and development of novel drug delivery systems or modified formulations to enhance its safety and efficacy profile.
Check Digit Verification of cas no
The CAS Registry Mumber 3805-37-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,8,0 and 5 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3805-37:
(6*3)+(5*8)+(4*0)+(3*5)+(2*3)+(1*7)=86
86 % 10 = 6
So 3805-37-6 is a valid CAS Registry Number.
3805-37-6Relevant articles and documents
Factors influencing the operational stability of NADPH-dependent alcohol dehydrogenase and an NADH-dependent variant thereof in gas/solid reactors
Kulishova, Liliya,Dimoula, Kerasina,Jordan, Max,Wirtz, Astrid,Hofmann, Diana,Santiago-Schuebel, Beatrix,Fitter, Joerg,Pohl, Martina,Spiess, Antje C.
experimental part, p. 271 - 283 (2011/02/22)
The continuous enzymatic gas/solid bio-reactor serves both for the production of volatile fine chemicals and flavors on an industrial scale and for thermodynamically controlled investigation of substrate and water effects on enzyme preparations for research purposes. Here, we comparatively investigated the molecular effects on the operational stability of NADPH-dependent Lactobacillus brevis alcohol dehydrogenase and an NADH-dependent variant thereof, LbADH G37D, in the gas/solid bioreactor. The reference reaction is the reduction of acetophenone to (R)-1-phenylethanol with concomitant oxidation of 2-propanol to acetone for the purpose of regeneration of the redox cofactor. It could be clearly shown that not the thermostability of the cofactor, but the thermostability of the proteins in the solid dry state govern the order of magnitude of the operational stability of both purified enzymes in the gas/solid reactor at low thermodynamic activity of water and substrate. However, at higher thermodynamic activity the operational stability in the gas/solid reactor is overlaid by stabilizing and destabilizing effects of the substrates that require further investigation. We demonstrated first evidence that the substrate affinity of the two variants in the gas/solid reactor is similar to the affinity in aqueous medium. We could also show that partial unfolding of the proteins with subsequent aggregation are the factors governing protein thermo-in-stability both in the dissolved and in the dry state. Thus, stability investigations of enzymes in the dry state are suggested to predict their basal level of operational stability in gas/solid reactions.
