38059-78-8

Basic information

• Product Name: O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE
• Synonyms: O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE;4-AMino-5-chloro-N-[2-(diethylaMino)ethyl]-2-hydroxy-benzaMide Hydrochloride
• CAS NO: 38059-78-8
• Molecular Formula: C₁₃H₂₀ClN₃O₂*ClH
• Molecular Weight: 322.23074
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites;Pharmaceuticals
• Mol File: 38059-78-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 237-239°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE(38059-78-8)
• EPA Substance Registry System: O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE(38059-78-8)

Safety Data

• Hazardous Substances Data: 38059-78-8(Hazardous Substances Data)

Usage

Description

O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE is a metabolite of Metoclopramide, which is a signal transducing dopamine D2 receptor antagonist. It is a white powder in its chemical form and is known for its antiemetic properties.

Uses

Used in Pharmaceutical Industry:
O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE is used as an active pharmaceutical ingredient for its antiemetic properties. It helps in treating nausea and vomiting by blocking the action of dopamine on the brain's chemoreceptor trigger zone, thus providing relief to patients experiencing these symptoms.
Used in Research and Development:
In the field of research and development, O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE is used as a novel metabolite of Metoclopramide for studying its effects on the dopamine D2 receptor and its potential applications in various medical conditions related to dopamine receptor antagonism.
Used in Drug Formulation:
O-DESMETHYL METOCLOPRAMIDE, HYDROCHLORIDE is used as a key component in the formulation of antiemetic medications. Its incorporation into drug formulations allows for the development of effective treatments for nausea and vomiting, particularly in cases where other antiemetic agents may not be suitable or effective.

Upstream product

• 364-62-5 metoclopramide 

Downstream Products

• 102670-98-4 tetra-n-butylammonium salt of 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-hydroxybenzamide 
• 114614-74-3 4-Amino-5-chloro-2-(5-chloro-pentyloxy)-N-(2-ethylamino-ethyl)-benzamide 
• 114614-52-7 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-oxiranylmethoxy-benzamide 
• 114633-61-3 4-Amino-5-chloro-2-[2-(2-chloro-ethoxy)-ethoxy]-N-(2-ethylamino-ethyl)-benzamide 
• 114614-73-2 4-Amino-5-chloro-2-(5-chloro-pentyloxy)-N-(2-diethylamino-ethyl)-benzamide 
• 114614-45-8 4-amino-5-chloro-N-<2-(diethylamino)ethyl>-2-(2-hydroxy-3-methoxypropoxy)benzamide 
• 114633-60-2 4-Amino-5-chloro-2-[2-(2-chloro-ethoxy)-ethoxy]-N-(2-diethylamino-ethyl)-benzamide 
• 102670-62-2 4-amino-2-<(2-oxobut-1-yl)oxy>-5-chloro-N-<2-(diethylamino)ethyl>benzamide 
• 102670-63-3 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(pentan-2-on-1-yl)oxybenzamide 
• 102670-67-7 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(1,1-dimethyl-2-oxo-propoxy)-benzamide 
• 102670-61-1 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-(pentan-2-on-3-yl)oxybenzamide 
• 114614-39-0 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo-cyclopentyloxy)-benzamide 
• 102670-48-4 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-oxo-cyclohexyloxy)-benzamide 
• 102670-69-9 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-(2-hydroxy-3-phenyl-propoxy)-benzamide 

Relevant articles and documents

PHARMACOLOGICALLY ACTIVE SUBSTITUTED BENZAMIDES

Novel substituted benzamides of the formula STR1 wherein R. sup.1, R 2, R 3, R 4, R 5 and A are as defined herein are useful in the treatment of emesis, and particularly chemotherapy-induced emesis in cancer patients. Some of the compounds are also useful in disorders relating to impaired gastric motility.