38127-55-8

Basic information

• Product Name: (2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine
• CAS NO: 38127-55-8
• Molecular Formula: C₈H₉N₃O₂
• Molecular Weight: 179.176
• Mol File: 38127-55-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 324.147°C at 760 mmHg
• Flash Point: 149.839°C
• Density: 1.221g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: (2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine(38127-55-8)
• EPA Substance Registry System: (2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine(38127-55-8)

Safety Data

• Hazardous Substances Data: 38127-55-8(Hazardous Substances Data)

Usage

General Description

(2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine is a chemical compound with the formula C9H10N4O2. It is an organic compound that contains a nitro group, a benzene ring, and a hydrazine functional group. It is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and ability to form various chemical bonds. (2E)-1-methyl-2-(4-nitrobenzylidene)hydrazine is also known for its potential applications in the field of organic chemistry and medicinal chemistry. It is important to handle this chemical with caution as it can be hazardous if not properly managed.

Upstream product

• 64-17-5 ethanol 
• 555-16-8 4-nitrobenzaldehdye 
• 60-34-4 methylhydrazine 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 38127-54-7 5,5-Dimethyl-3-{N-methyl-N'-[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-hydrazino}-cyclohex-2-enone 
• 40093-40-1 C₁₃H₁₈N₄O₂S 
• 135676-88-9 1-Methyl-3-(4-nitro-phenyl)-4,6-diphenyl-1,2,3,4-tetrahydro-[1,2,4,5]tetrazine 
• 135676-61-8 C₁₇H₁₇N₅O₃ 
• 134122-68-2 1-methyl-3-(p-nitrophenyl)-5-(D-galacto-pentitol-1-yl)pyrazole 
• 134122-60-4 1-methyl-3-(p-nitrophenyl)-5-(1,2,3,4,5-penta-O-acetyl-D-galacto-pentitol-1-yl)pyrazole 
• 134122-57-9 p-nitrobenzaldehyde N-methyl-N-(3,4,5,6,7-penta-O-acetyl-1,2-dideoxy-1-nitro-D-galacto-heptitol-2-yl)hydrazone 
• 135701-11-0 C₁₇H₁₇N₅O₄ 
• 64643-24-9 (2E)-3-[1-methyl-2-(4-nitro-benzylidene)-hydrazino]-crotonic acid ethylester 
• 41555-57-1 3-{N-Methyl-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-cyclohex-2-enone 
• 41555-77-5 2-Methyl-3-{N-methyl-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-cyclopent-2-enone 
• 135677-04-2 1-Acetyl-2-methyl-6-(4-nitro-phenyl)-5-phenyl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazine-3-carboxylic acid methyl ester 
• 64486-99-3 3-{N-Methyl-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-butyric acid ethyl ester 
• 64487-04-3 N-Methyl-N-(4-nitro-benzyl)-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazine 

Relevant articles and documents

Biophysically defined and cytocompatible covalently adaptable networks as viscoelastic 3d cell culture systems

Presented here is a cytocompatible covalently adaptable hydrogel uniquely capable of mimicking the complex biophysical properties of native tissue and enabling natural cell functions without matrix degradation. Demonstrated is both the ability to control elastic modulus and stress relaxation time constants by more than an order of magnitude while predicting these values based on fundamental theoretical understanding and the simulation of muscle tissue and the encapsulation of myoblasts.

Preparation of 5-Aryl-2-Alkyltetrazoles with Aromatic Aldehydes, Alkylhydrazine, Di-tert-butyl Azodicarboxylate, and [Bis(trifluoroacetoxy)iodo]benzene

A variety of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles were directly prepared in good to moderate yields by the reaction of aromatic aldehydes with methylhydrazine and benzylhydrazine, followed by treatment with di-tert-butyl azodicarboxylate and [bis(trifluoroacetoxy)iodo]benzene in a mixture of dichloromethane and 2,2,2-trifluoroethanol at room temperature. The present method is a novel one-pot preparation of 5-aryl-2-methyltetrazoles and 5-aryl-2-benzyltetrazoles through a [2N + 2N] combination under transition metal-free and mild conditions.

Regioselective Synthesis of 4-Nitro- or 4-Chloro-Tetrasubstituted Pyrazoles from Hydrazones and β-Halo-β-nitrostyrenes

We report an acid-catalyzed cycloaddition reaction of hydrazones with β-bromo- or β-chloro-β-nitrostyrenes for the regioselective synthesis of 4-nitro- or 4-chloro-tetrasubstituted pyrazoles. Arising from a common 4-halo-4-nitropyrazolidine intermediate,