3814-19-5

Basic information

• Product Name: Ethanone, 1-(3-mercaptophenyl)-
• Synonyms: 3'-mercaptoacetophenone;m-Mercapto-acetophenon;m-Acetylthiophenol;3-ethanoylthiophenol
• CAS NO: 3814-19-5
• Molecular Formula: C8H8OS
• Molecular Weight: 152.217
• Mol File: 3814-19-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 137 °C(Press: 11 Torr)
• Density: 1.139±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Ethanone, 1-(3-mercaptophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(3-mercaptophenyl)-(3814-19-5)
• EPA Substance Registry System: Ethanone, 1-(3-mercaptophenyl)-(3814-19-5)

Safety Data

• Hazardous Substances Data: 3814-19-5(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(3-mercaptophenyl)-, also known as 3-Mercaptophenylacetone, is a chemical compound with the molecular formula C9H10OS. It is a colorless to pale yellow liquid with a pungent odor and is insoluble in water but soluble in organic solvents. Ethanone, 1-(3-mercaptophenyl)- is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a fragrance ingredient and in the production of polymers. Additionally, it has been studied for its potential use in the treatment of certain medical conditions such as hypertension and inflammation. However, it is important to handle this chemical with care as it can be harmful if ingested, inhaled, or comes into contact with the skin.

Upstream product

• 1052081-55-6 3-[(3-acetylphenyl)thio]propionic acid 2-ethylhexyl ester 
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Downstream Products

• 1441-99-2 1-[3-(methylsulfanyl)phenyl]ethan-1-one 
• 1021157-58-3 1-[3-(cyclopentylthio)phenyl]ethanone 
• 89102-48-7 2-bromo-1-(3-mercaptophenyl)ethanone 
• 1351823-47-6 4-(5-bromothiophen-2-yl)-6-(3-(ethylthio)phenyl)-2,2'-bipyridine 
• 1351823-45-4 1-(2-(3-(ethylthio)phenyl)-2-oxoethyl)pyridinium iodide 
• 1351823-51-2 4-(5-(6-(3-(ethylthio)phenyl)-2,2'-bipyridin-4-yl)thiophen-2-yl)-N,N-bis(4-methoxyphenyl)aniline 
• 1351823-50-1 4-(5-(6-(3-(ethylthio)phenyl)-2,2'-bipyridin-4-yl)thiophen-2-yl)-N,N-diphenylaniline 
• 1052081-60-3 1-(3-(ethylthio)phenyl)ethanone 
• 1052081-65-8 3'-(4-nitrophenylthio)acetophenone 
• 94001-58-8 1-(3-methylsulfanyl-phenyl)-1-phenyl-ethanol 
• 40897-44-7 Di(m-acetylphenyl)disulfid 
• 19654-42-3 (m-Acetylphenyl)-N,N-dimethylthiocarbamat 

Relevant articles and documents

Discovery of 3,5-Dimethyl-4-Sulfonyl-1 H-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability

Myeloid cell leukemia 1 (Mcl-1) protein is a key negative regulator of apoptosis, and developing Mcl-1 inhibitors has been an attractive strategy for cancer therapy. Herein, we describe the rational design, synthesis, and structure-activity relationship study of 3,5-dimethyl-4-sulfonyl-1H-pyrrole-based compounds as Mcl-1 inhibitors. Stepwise optimizations of hit compound 11 with primary Mcl-1 inhibition (52%@30 μM) led to the discovery of the most potent compound 40 with high affinity (Kd = 0.23 nM) and superior selectivity over other Bcl-2 family proteins (>40,000 folds). Mechanistic studies revealed that 40 could activate the apoptosis signal pathway in an Mcl-1-dependent manner. 40 exhibited favorable physicochemical properties and pharmacokinetic profiles (F% = 41.3%). Furthermore, oral administration of 40 was well tolerated to effectively inhibit tumor growth (T/C = 37.3%) in MV4-11 xenograft models. Collectively, these findings implicate that compound 40 is a promising antitumor agent that deserves further preclinical evaluations.

Copper(II)-Catalyzed Single-Step Synthesis of Aryl Thiols from Aryl Halides and 1,2-Ethanedithiol

A highly efficient transition metal-catalyzed single-step synthesis of aryl thiols from aryl halides has been developed employing copper(II) catalyst and 1,2-ethanedithiol. The key features are use of readily available reagents, a simple operation, and relatively mild reaction conditions. This new protocol shows a broad substrate scope with excellent functional group compatibility. A variety of aryl thiols are directly prepared from aryl halides in high yields. Furthermore, the aryl thiols are used in situ for the synthesis of more advanced molecules such as diaryl sulfides and benzothiophenes.

Regioselective C-H activation of cyclometalated bis-tridentate ruthenium complexes

A series of bis-tridentate Ru(II) complexes consisting of trimethyl-4,4′,4″-tricarboxylate-2,2′:6′, 2″-terpyridine (Me3tctpy) and derivatized 6-phenyl-2,2′- bipyridine (pbpy) ligands are reported. Each complex is attached to a terminal tripheny