38150-49-1

Basic information

• Product Name: DL-ALPHA-(3-THIENYL)GLYCINE
• Synonyms: RARECHEM AK ML 0430;AMINO-THIOPHEN-3-YL-ACETIC ACID;2-AMINO-2-(3-THIENYL)ACETIC ACID;DL-ALPHA-(3-THIENYL)GLYCINE;alpha-(3-thienyl)glycine;dl-A-(3-thienyl)glycine;DL-alpha-aminothiophen-3-acetic acid;dl-α-(3-thienyl)glycine
• CAS NO: 38150-49-1
• Molecular Formula: C₆H₇NO₂S
• Molecular Weight: 157.19
• Product Categories: Amino Acid Derivatives;Amino Acids;I - Z;Modified Amino Acids
• Mol File: 38150-49-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 238℃
• Boiling Point: 317.5 °C at 760 mmHg
• Flash Point: 145.8 °C
• Appearance: /
• Density: 1.418
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.89±0.10(Predicted)
• CAS DataBase Reference: DL-ALPHA-(3-THIENYL)GLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-ALPHA-(3-THIENYL)GLYCINE(38150-49-1)
• EPA Substance Registry System: DL-ALPHA-(3-THIENYL)GLYCINE(38150-49-1)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 38150-49-1(Hazardous Substances Data)

Usage

General Description

DL-ALPHA-(3-THIENYL)GLYCINE is a chemical compound categorized as an alpha-amino acid that includes a thienyl side chain. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. DL-ALPHA-(3-THIENYL)GLYCINE has also shown potential as a precursor in the development of new drugs for the treatment of neurological disorders, as well as in the field of medicinal chemistry. Additionally, DL-ALPHA-(3-THIENYL)GLYCINE has been studied for its potential as an ingredient in the development of novel materials and as a component in the production of agrochemicals. Its versatile properties make it a valuable component in the research and development of various industrial and medicinal applications.

Upstream product

• 97101-16-1 (2S)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure 
• 498-62-4 3-thiophene carboxaldehyde 
• 97036-24-3 (4S,5S)-(+)-2,2-Dimethyl-4-phenyl-5-<(3-thienylmethylen)amino>-1,3-dioxan 
• 97036-28-7 (2S)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(3-thienyl)acetonitril 
• 97036-30-1 (2R)-(-)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-thienyl)essigsaeure 
• 97036-26-5 (2R)-(+)-2-<(4S,5S)-(2,2-Dimethyl-4-phenyl-1,3-dioxan-5-yl)amino>-2-(3-thienyl)acetonitril 

Downstream Products

• 73-32-5 DL-isoleucine 
• 126823-57-2 N-<(o-nitrophenyl)sulfenyl>-D,L-3-thienylglycine 
• 470670-70-3 2,5-dioxo-4-thiophen-3-yl-oxazolidine-3-carboxylic acid benzyl ester 
• 126823-63-0 N-<(o-nitrophenyl)sulfenyl>-D,L-3-thienylglycine (+)-β-fenchyl ester 
• 40512-57-0 (±)-2-(tert-butoxycarbonylamino)-2-(thiophen-3-yl)acetic acid 
• 891789-94-9 C₁₃H₁₁ClN₂O₃S 
• 1183538-72-8 2-amino-2-(thiophen-3-yl)ethan-1-ol 

Relevant articles and documents

Nonproteinogenic Amino Acids, III. - Syntheses of the Enantiomerically Pure 2-(2-Thienyl)- and 2-(3-Thienyl)glycines. - Molecular Structure of the Intermediate Schiff's Bases

The syntheses of enantiomerically pure D-(-)- and L-(+)-2-(2-thienyl)- and 2-(3-thienyl)glycines (6a-d) are described.Preparing the amino nitriles 4 directly from 2-thiophenecarbaldehyde (1a) or 3-thiophenecarbaldehyde (1b), respectively, and (4S,5S)-(+)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane (2), and hydrocyanic acid (one-step procedure), the aminonitriles 4a and 4b, respectively, are formed in excess.By crystallization they are obtained diastereomerically pure leading to enantiomerically pure D-amino acids 6a and 6b.If, however, the intermediate Schiff's bases 3 are isolated as crystals and then converted with hydrocyanic acid into the respective aminonitriles 4 (two-step procedure), the diastereomeric aminonitriles 4c and 4d, respectively, crystallize resulting in enantiomerically pure L-amino acids 6a and 6d.X-ray structure analyses of the Schiff's bases 3c and 3e revealed the previously postulated E-configuration of the C=N bond and its chiral shielding by the phenyl substituent at C4.