38155-18-9

Basic information

• Product Name: L-Phenylalanine, N-L-leucyl-, methyl ester
• Synonyms: (S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-phenyl-propionic acid methyl ester;N-L-leucyl-L-phenylalanine methyl ester;H-Leu-Phe-OMe;Leu-Phe-OMe;L-Leu-L-Phe-OMe
• CAS NO: 38155-18-9
• Molecular Formula: C16H24N2O3
• Molecular Weight: 292.378
• Mol File: 38155-18-9.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 457.4±40.0 °C(Predicted)
• Density: 1.088±0.06 g/cm3(Predicted)
• CAS DataBase Reference: L-Phenylalanine, N-L-leucyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-L-leucyl-, methyl ester(38155-18-9)
• EPA Substance Registry System: L-Phenylalanine, N-L-leucyl-, methyl ester(38155-18-9)

Safety Data

• Hazardous Substances Data: 38155-18-9(Hazardous Substances Data)

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 35661-60-0 Fmoc-Leu-OH 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 61-90-5 L-leucine 
• 67-56-1 methanol 
• 3063-05-6 Leu-Phe-OH 
• 2018-66-8 Z-Leu-OH 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 103321-59-1 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine, acid chloride 
• 827018-96-2 Fmoc-Leu-Phe-OMe 
• 88224-03-7 L-leucine allyl ester hydro-p-toluenesulfonate 
• 15136-32-0 (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester 
• 10473-38-8 N-(benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester 

Downstream Products

• 1133960-39-0 C₅₃H₇₁N₃O₈Si 
• 15136-13-7 N-tert-butoxycarbonyl-L-leucyl-L-leucine methyl ester 
• 73401-65-7 (S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoic acid 
• 1224467-09-7 N-phenyl-L-leucine-L-phenylalanine methyl ester 
• 868539-96-2 (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate 
• 1428376-99-1 C₃₀H₄₁N₃O₇ 
• 1357008-48-0 C₂₁H₃₁N₅O₄ 
• 1357007-68-1 C₃₃H₅₁N₇O₄ 
• 1357007-92-1 C₃₃H₅₁N₇O₄ 
• 1357007-90-9 C₂₀H₂₉N₅O₄ 
• 1357008-03-7 C₃₆H₅₅N₅O₇S 

Relevant articles and documents

Utilization of 2-(4-Nitrophenylsulfonyl)ethoxycarbonyl (Nsc) as a substitute for 9H-fluoren-9-ylmethoxycarbonyl (Fmoc) in liquid phase chemistry

2-(4-Nitrophenylsulfonyl)ethoxycarbonyl (Nsc) is a useful substitute for the Fmoc group. It is easily removed not only with secondary amines but with tris(aminoethyl)amine (TAEA) and with resin-bound TAEA, thus allowing for a simplified work-up: the side products of the deprotection are removed either by extraction with phosphate buffer or by filtration.

A dipeptide-based superhydrogel: Removal of toxic dyes and heavy metal ions from waste water

A short peptide-based molecule has been found to form a strong hydrogel at phosphate buffer solution of pH 7.46. The hydrogel has been characterized thoroughly using various techniques including field emission scanning electron microscopy (FE-SEM), wide angle powder X-ray diffraction (PXRD), and rheological analysis. It has been observed from FE-SEM images that entangled nanofiber network is responsible for gelation. Rheological investigation demonstrates that the self-assembly of this synthetic dipeptide results in the formation of mechanically strong hydrogel with storage modulus (G′) around 104 Pa. This gel has been used for removing both cationic and anionic toxic organic dyes (Brilliant Blue, Congo red, Malachite Green, Rhodamine B) and metal ions (Co2+ and Ni2+) from waste water. Moreover, only a small amount of the gelator is required (less than 1 mg/mL) for preparation of this superhydrogel and even this hydrogel can be reused three times for dye/metal ion absorption. This signifies the importance of the hydrogel towards waste water management.

Room temperature N-arylation of amino acids and peptides using copper(i) and β-diketone

A mild and efficient method for the N-arylation of zwitterionic amino acids, amino acid esters and peptides is described. The procedure provides the first room temperature synthesis of N-arylated amino acids and peptides using CuI as a catalyst, diketone as a ligand, and aryl iodides as coupling partners. The method is equally applicable for using relatively inexpensive aryl bromides as coupling partners at 80 °C. Using this procedure, electronically and sterically diverse aryl halides, containing reactive functional groups were efficiently coupled in good to excellent yields.