38199-89-2

Basic information

• Product Name: 1-(4-methoxyphenyl)-2,3-dihydro-1H-indene
• CAS NO: 38199-89-2
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.2976
• Mol File: 38199-89-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 341.9°C at 760 mmHg
• Flash Point: 135.6°C
• Density: 1.085g/cm³
• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 1-(4-methoxyphenyl)-2,3-dihydro-1H-indene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2,3-dihydro-1H-indene(38199-89-2)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2,3-dihydro-1H-indene(38199-89-2)

Safety Data

• Hazardous Substances Data: 38199-89-2(Hazardous Substances Data)

Usage

Description

1-(4-methoxyphenyl)-2,3-dihydro-1H-indene, also known as p-Methoxydihydroindene, is a chemical compound characterized by its molecular formula C15H14O and a molecular weight of 210.27 g/mol. It presents as a white to off-white solid with a melting point of 89-92°C. 1-(4-methoxyphenyl)-2,3-dihydro-1H-indene is recognized for its versatile applications in the chemical, pharmaceutical, and flavor industries.

Uses

Used in Pharmaceutical Synthesis:
1-(4-methoxyphenyl)-2,3-dihydro-1H-indene is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to be a building block in the creation of medicinal compounds.
Used in Organic Chemistry:
In the field of organic chemistry, 1-(4-methoxyphenyl)-2,3-dihydro-1H-indene is utilized as a fundamental component in the development of new chemical structures and materials.
Used in Fragrance and Flavor Production:
1-(4-methoxyphenyl)-2,3-dihydro-1H-indene is employed as a component in the production of fragrances and flavors, capitalizing on its chemical properties to enhance the sensory qualities of products.
Used in Chemical Manufacturing:
1-(4-methoxyphenyl)-2,3-dihydro-1H-indene also serves as an intermediate in the manufacture of other chemicals, contributing to the diversification of chemical products and applications.
Used in Therapeutic Applications:
1-(4-methoxyphenyl)-2,3-dihydro-1H-indene has been investigated for its potential therapeutic uses, particularly in the treatment of various diseases and conditions, highlighting its significance in the healthcare sector.

Upstream product

• 35275-62-8 1-chloroindane 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 5402-37-9 4-(2,3-dihydro-1H-inden-1-yl)phenol 
• 77-78-1 dimethyl sulfate 
• 100-66-3 methoxybenzene 
• 95-13-6 1-indene 
• 38135-26-1 2-bromo-1-methoxyindane 
• 1194-56-5 1-methyleneindane 
• 696-62-8 para-iodoanisole 
• 38199-92-7 3-(4-methoxyphenyl)-1H-indene 
• 73424-46-1 N'-(2,3-dihydro-1H-inden-1-ylidene)-4-methylbenzenesulfonohydrazide 
• 5720-07-0 4-methoxyphenylboronic acid 
• 6351-10-6 1-Indanol 

Downstream Products

• 5402-37-9 4-(2,3-dihydro-1H-inden-1-yl)phenol 

Relevant articles and documents

BH3 ? Me2S: An Alternative Hydride Source for NiH-Catalyzed Reductive Migratory Hydroarylation and Hydroalkenylation of Alkenes

Borane dimethylsulfide (BMS) was found to be an efficient hydride source for nickel-hydride catalyzed reductive migratory hydrofunctionalization reactions. Catalytic reductive migratory hydroarylation and migratory hydroalkenylation were achieved with BMS in high yields and with excellent regioselectivity. A large-scale experiment employing as little as 0.5 equivalents of BH3 ? Me2S as the hydride source delivered the desired migratory hydroarylation product in high yield and selectivity.

Bisoxazoline-pincer ligated cobalt-catalyzed hydrogenation of alkenes

The efficient and atom economical hydrogenation of alkenes using a novel bisoxazoline ligated cobalt complex has been developed. The hydrogenation of a variety of alkenes containing electron neutral and electron-donating groups proceeds in high yield, whi

Synthesis of 1-aryl- benzocycloalkane derivatives via one-pot two-step reaction of benzocyclonone, tosylhydrazide, and arylboronic acid

A metal-free one-pot two-step reductive coupling reaction of benzocyclonone, tosylhydrazide, and arylboronic acid was developed for the formation of a C(sp3)–C(sp2) bond, which enabled the efficient synthesis of 1-aryl-benzocycloalkane compounds in moderate to good yields on a multi-gram scale. Moreover, five- and six-membered benzocyclic ketones are also suitable substrates for this reaction. Notably, this protocol was also found to be suitable for synthesizing 3-(3,4-dichlorophenyl)-2,3-dihydro-1H-inden-1-one, an important intermediate in the synthesis of indatraline.