38210-27-4Relevant articles and documents
Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A
Li, Qiao,Zhuang, Chen,Wang, Donghua,Zhang, Wei,Jia, Rongxuan,Sun, Fengxia,Zhang, Yilin,Du, Yunfei
supporting information, p. 2958 - 2965 (2020/01/08)
The construction of the biologically interesting chromone skeleton was realized by PhIO-mediated dehydrogenation of chromanones under mild conditions. Interestingly, this method also found application in the synthesis of the naturally occurring frutinone A.
Flavonoid compound Frutinones A, B and C synthetic method
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, (2017/08/25)
The invention relates to a synthesis method of flavonoid natural compounds Frutinones A, B and C. The synthesis method comprises the following steps: synthesizing an intermediate 3-benzoyl-4-hydroxycoumarin derivative from the raw materials including cheap 4-hydroxycoumarin and analogues thereof; and performing a key step of nucleophilic substitution on a benzene ring to obtain target products Frutinones A, B and C. The synthesis method can overcome the shortcomings of the prior art and is an atom economic synthesis route. The synthesis method provided by the invention has the characteristics of simple and convenient synthesis route, simplicity in operation, cheap raw materials and safety and practicability and particularly high yield, good stability and relatively wide applicability.
Efficient synthesis of frutinone A and its derivatives through palladium-catalyzed C-H activation/carbonylation
Shin, Yongje,Yoo, Changho,Moon, Youngtaek,Lee, Yunho,Hong, Sungwoo
, p. 878 - 881 (2015/04/14)
Frutinone A, a biologically active ingredient of an antimicrobial herbal extract, demonstrates potent inhibitory activity towards the CYP1A2 enzyme. A three-step total synthesis of frutinone A with an overall yield of 44 is presented. The construction of
