382142-89-4

Basic information

• Product Name: (2S)-(2,2-dichloroacetylamino)-(3R)-hydroxy-3-(4-nitrophenyl)-propionic acid ethyl ester
• Synonyms: (2S)-(2,2-dichloroacetylamino)-(3R)-hydroxy-3-(4-nitrophenyl)-propionic acid ethyl ester
• CAS NO: 382142-89-4
• Molecular Weight: 365.17
• Mol File: 382142-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-(2,2-dichloroacetylamino)-(3R)-hydroxy-3-(4-nitrophenyl)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-(2,2-dichloroacetylamino)-(3R)-hydroxy-3-(4-nitrophenyl)-propionic acid ethyl ester(382142-89-4)
• EPA Substance Registry System: (2S)-(2,2-dichloroacetylamino)-(3R)-hydroxy-3-(4-nitrophenyl)-propionic acid ethyl ester(382142-89-4)

Safety Data

• Hazardous Substances Data: 382142-89-4(Hazardous Substances Data)

Upstream product

• 66607-69-0 4-nitrobenzylidenediphenylmethylamine 
• 555-16-8 4-nitrobenzaldehdye 
• 79-43-6 dichloro-acetic acid 
• 382142-90-7 cis-1-benzhydryl-(3S)-(4-nitrophenyl)-aziridine-(2S)-carboxylic acid ethyl ester 

Downstream Products

• 56-75-7 chloramphenicol 

Relevant articles and documents

An efficient synthesis of (-)-chloramphenicol via asymmetric catalytic aziridination: a comparison of catalysts prepared from triphenylborate and various linear and vaulted biaryls.

[reaction--see text] The antibiotic (-)-choramphenicol has been synthesized in only four steps from p-nitro-benzaldehyde in optically pure form from an asymmetric catalytic aziridination reaction with a chiral catalyst prepared from triphenylborate and the (R)-VAPOL ligand. Catalysts generated from the VAPOL and VANOL ligands give much higher asymmetric induction than do catalysts prepared from 6,6'-diphenylVAPOL, BINOL, and BANOL ligands.