38221-55-5

Basic information

• Product Name: 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE
• Synonyms: TIMTEC-BB SBB001855;2-CHLORO-1-[2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZIN-10-YL]-1-ETHANONE;2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE;2-Chloro-1-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)ethanone;2-chloro-1-[2-(trifluoromethyl)-10-phenothiazinyl]ethanone
• CAS NO: 38221-55-5
• Molecular Formula: C₁₅H₉ClF₃NOS
• Molecular Weight: 343.75
• Mol File: 38221-55-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 502.6 °C at 760 mmHg
• Flash Point: 257.8 °C
• Appearance: /
• Density: 1.476g/cm³
• Vapor Pressure: 3.13E-10mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE(38221-55-5)
• EPA Substance Registry System: 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE(38221-55-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 38221-55-5(Hazardous Substances Data)

Usage

General Description

2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE is a chemical compound with the molecular formula C17H11ClF3N2OS. It belongs to the class of phenothiazine derivatives and contains a chloro and trifluoromethyl group in its structure. 2-CHLORO-1-(2-TRIFLUOROMETHYL-PHENOTHIAZIN-10-YL)-ETHANONE is primarily used in the pharmaceutical industry for the synthesis of potential drug candidates and research purposes. It is known for its diverse pharmacological properties, including antipsychotic, antimicrobial, and anticancer activities. Additionally, it exhibits interesting biological and chemical properties that make it a valuable tool in drug discovery and development.

InChI:InChI=1/C15H9ClF3NOS/c16-8-14(21)20-10-3-1-2-4-12(10)22-13-6-5-9(7-11(13)20)15(17,18)19/h1-7H,8H2

Upstream product

• 92-30-8 2-(trifluoromethyl)-10H-phenothiazine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1870-11-7 2-trifluoromethyl-10-[(2,4,6-trioxo-5-phenyl-hexahydro-pyrimidin-5-yl)-acetyl]-10H-phenothiazine 
• 352016-78-5 2-{2-oxo-2-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]ethyl}-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Rational design, synthesis and antitubercular evaluation of novel 2-(trifluoromethyl)phenothiazine-[1,2,3]triazole hybrids

Molecular hybridization is an emerging structural modification tool to design molecules with better pharmacophoric properties. A series of novel 2-(trifluoromethyl)phenothiazine-1,2,3-triazoles 5a-v designed by hybridizing two antitubercular drugs trifluoperazine and I-A09 in a single molecular architecture, were synthesized in very good yields using click chemistry. Among the all '22' compounds screened for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (Mtb), three analogs 5c, 5l and 5o were found to be most potent (MIC: 6.25 μg/mL) antitubercular agents with good selectivity index.

Phenothiazines nitric oxide donor, its preparation and use

The invention discloses a kind of phenothiazine-containing nitric oxide donor compounds with the structure of a formula I. In the formula I, n is equal to 0, 1 or 2, R1 is hydrogen, halogens, C1-C4 branched or linear alkyl, or halogenated C1-C4 branched or linear alkyl, and R2 is hydrogen or C1-C4 branched or linear alkyl. The invention also discloses a preparation method of the compounds, and discloses a pharmaceutical composition taking the compounds as an active composition, and application of the compounds as anti-tumor medicines, especially to prepare medicines for treating breast cancer, lung cancer and stomach cancer.

Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines

A series of 2-substituted N-acylphenothiazines were synthesized by using imides, N-carboxymethyl imides and the structures of these newly synthesized compounds were confirmed by spectral and elemental analyses. All new compounds were tested for their antibacterial and antifungal activities. Some compounds showed promising antibacterial and antifungal activities.