3824-45-1

Basic information

• Product Name: 4,6-dichloro-2-fluoropyriMidine
• Synonyms: 4,6-dichloro-2-fluoropyriMidine;2-fluoro-4,6-dichloropyrimidine
• CAS NO: 3824-45-1
• Molecular Formula: C₄HCl₂FN₂
• Molecular Weight: 166.9685432
• Mol File: 3824-45-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4,6-dichloro-2-fluoropyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-2-fluoropyriMidine(3824-45-1)
• EPA Substance Registry System: 4,6-dichloro-2-fluoropyriMidine(3824-45-1)

Safety Data

• Hazardous Substances Data: 3824-45-1(Hazardous Substances Data)

Usage

Synthesis

HF techniques have been found to work excellently if used with bases such as pyridine. Workers applied this to the synthesis of a range of fluoroheterocycles,for example, 3-fluoropyridine, 2-fluoro-3-nitropyridine and 2-fluoro-4,6-dichloropyrimidine were made in good yield.

Upstream product

• 3764-01-0 2,4,6-trichloropyrimidine 

Relevant articles and documents

LES FLUORATIONS COMPAREES DES CHLOROPYRIMIDINES ET DE LA CHLORO-S-TRIAZINE

The fluorinations of tetrachloropyrimidine, 2,4,6-trichloropyrimidine and trichloro-s-triazine were carried out in sealed tubes with KF in presence of inert gas and then compared.The fluorinated derivatives C4FxClyN2 with x + y = 4, O - were investigated and compared; the molar yields were found to be always higher than 50percent in our experimental conditions.We compare with the fluorinations of 2,4 and 4,6-dichloropyrimidine.It is possible to obtain directlyin good proportions, such fluorinated derivatives as 5-chlorotrifluoropyrimidine, trifluoropyrimidine and others.At high temperature (4OO deg C for 16h), tetrachloropyrimidine, in presence of KF, gave products of pyrolysis and condensation such as the fluorinated derivatives of C6Cl6 and C5Cl5N: C6FCl5, C6F2Cl4... or C5FCl4N, C5F2Cl3N...