3826-47-9

Basic information

• Product Name: 2-(2-fluorophenyl)-1-phenylethan-1-one
• Synonyms: 2-(2-fluorophenyl)-1-phenylethan-1-one;2-(2-Fluorophenyl)-1-phenylethanone;α-(2-Fluorophenyl)acetophenone
• CAS NO: 3826-47-9
• Molecular Formula: C₁₄H₁₁FO
• Molecular Weight: 214.2349432
• EINECS: 223-322-5
• Mol File: 3826-47-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 321.7°Cat760mmHg
• Flash Point: 132.6°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0.000293mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 2-(2-fluorophenyl)-1-phenylethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorophenyl)-1-phenylethan-1-one(3826-47-9)
• EPA Substance Registry System: 2-(2-fluorophenyl)-1-phenylethan-1-one(3826-47-9)

Safety Data

• Hazardous Substances Data: 3826-47-9(Hazardous Substances Data)

Usage

Class

Ketones

Physical form

White to light yellow crystalline powder

Uses

Synthesis of pharmaceuticals and organic compounds, potential application in organic photovoltaics, manufacture of flavoring agents, adhesives, and coatings

Safety precautions

May be harmful if inhaled, swallowed, or comes into contact with the skin

InChI:InChI=1/C14H11FO/c15-13-9-5-4-8-12(13)10-14(16)11-6-2-1-3-7-11/h1-9H,10H2

Upstream product

• 19348-89-1 diphenyl {[(4-nitrophenyl)amino](phenyl)methyl}phosphonate 
• 446-52-6 2-Fluorobenzaldehyde 
• 348-51-6 1-chloro-2-fluorobenzene 
• 96-22-0 pentan-3-one 
• 98-86-2 acetophenone 
• 100-52-7 benzaldehyde 
• 785-81-9 4-nitro-N-(phenylmethylene)benzenamine 
• 1072-85-1 o-fluorobromobenzene 
• 2522-81-8 2-<(2,2-dimethylpropanoyl)oxy>-1-phenylethanone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 134-81-6 benzil 
• 702701-86-8 1-(2-fluorophenyl)-2-oxo-2-phenylethyl benzoate 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 71-43-2 benzene 

Downstream Products

• 129448-67-5 1-phenyl-2-(2-fluorophenyl)-3-(3-methoxyphenyl)-1-propanone 
• 126348-31-0 2-(2-fluorophenyl)-1-phenylprop-2-en-1-one 
• 126348-37-6 3-(2-fluorophenyl)-4-phenylbutanol 
• 126348-36-5 3-(2-fluorophenyl)-4-phenylbutanoic acid 
• 126348-34-3 3-benzoyl-3-(2-fluorophenyl)propanoic acid 
• 126348-33-2 3-benzoyl-3-(2-fluorophenyl)propionamide 
• 126348-32-1 3-benzoyl-3-(2-fluorophenyl)propiononitrile 
• 126348-35-4 3-(2-fluorophenyl)-3-<2-(2-phenyl-1,3-dithiolanyl)>propionic acid 
• 1443223-46-8 2-(3,5-dimethylphenyl)-2-(2-fluorophenyl)-1-phenylethanone 
• 1283117-10-1 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-(2-fluorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 10604-22-5 3-phenylcinnoline 
• 3834-64-8 1-(2-fluorophenyl)-2-phenylethane-1,2-dione 

Relevant articles and documents

Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+System

Chemoselective deprotonative functionalization of benzylic C-H bonds is challenging, because the arene ring contains multiple aromatic C(sp2)-H bonds, which can be competitively deprotonated and lead to selectivity issues. Recently it was found that bimetallic [MN(SiMe3)2 M = Li, Na]/Cs+ combinations exhibit excellent benzylic selectivity. Herein, is reported the first deprotonative addition of toluenes to Weinreb amides mediated by LiN(SiMe3)2/CsF for the synthesis of a diverse array of 2-arylacetophenones. Surprisingly, simple methyl benzoates also react with toluenes under similar conditions to form 2-arylacetophenones without double addition to give tertiary alcohol products. This finding greatly increases the practicality and impact of this chemistry. Some challenging substrates with respect to benzylic deprotonations, such as fluoro and methoxy substituted toluenes, are selectively transformed to 2-aryl acetophenones. The value of benzylic deprotonation of 3-fluorotoluene is demonstrated by the synthesis of a key intermediate in the preparation of Polmacoxib.

Ruthenium(II)-Catalyzed Cross-Coupling of Benzoyl Formic Acids with Toluenes: Synthesis of 2-Phenylacetophenones

Herein, we report a direct method to synthesize 2-phenylacetophenone through a ruthenium(II)-catalyzed cross-coupling reaction between acyl and benzyl radical. The various derivatives of 2-phenylacetophenone were prepared easily in moderate to good yields. These reactions provide a straightforward pathway to synthesize a variety of ketones bearing various functional groups.

SMALL MOLECULE INHIBITORS OF ACETYL COENZYME A SYNTHETASE SHORT CHAIN 2 (ACSS2)

The present invention relates to compounds of formula (I). The compounds may be used to modulate the acetyl coenzyme A synthetase short chain 2 (ACSS2) protein and may thereby treat, ameliorate or prevent a disease selected from cancer, bacterial infection, viral infection, parasitic infection, fungal infection, neurodegenerative disease, neurological disorder, cerebrovascular disease, cardiovascular disease, non- alcoholic fatty liver disease and obesity. Alternatively, or additionally, the compounds maybe used to promote healthy ageing.