38261-78-8

Basic information

• Product Name: (H-CYS-OTBU)2 2 HCL
• Synonyms: L-CYSTINE BIS(T-BUTYL ESTER) DIHYDROCHLORIDE;(H-CYS-OTBU)2 2 HCL;(H-Cys-OtBu)2 . 2 HCl, (Disulfide bond);(H-Cys-OtBu)2;L-Cystine bis(tert-butyl ester) dihydrochloride;(2R,2'R)-Di-tert-butyl 3,3'-disulfanediylbis(2-aMinopropanoate) dihydrochloride;(Cys-otbu)2.2Hcl;(L-Cys-OtBu)2·2HCl
• CAS NO: 38261-78-8
• Molecular Formula: C₁₄H₂₈N₂O₄S₂*2ClH
• Molecular Weight: 425.43
• EINECS: 1308068-626-2
• Mol File: 38261-78-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (H-CYS-OTBU)2 2 HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (H-CYS-OTBU)2 2 HCL(38261-78-8)
• EPA Substance Registry System: (H-CYS-OTBU)2 2 HCL(38261-78-8)

Safety Data

• Hazardous Substances Data: 38261-78-8(Hazardous Substances Data)

Usage

Description

(H-CYS-OTBU)2 2 HCL, also known as L-Cystine Bis(T-butyl Ester) Dihydrochloride, is a white solid chemical compound derived from L-cystine, a non-essential amino acid. It is characterized by its unique chemical structure, which includes a disulfide bond and t-butyl ester groups. (H-CYS-OTBU)2 2 HCL is known for its potential applications in various fields due to its chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
(H-CYS-OTBU)2 2 HCL is used as a reagent for the synthesis of chelate oxorhenium, which is crucial in creating new integrin antagonists. Integrin antagonists are important in the development of drugs targeting various diseases, including cancer and autoimmune disorders. (H-CYS-OTBU)2 2 HCL's ability to form chelates with oxorhenium enhances its utility in this application.
Used in Chemical Synthesis:
As a white solid with unique chemical properties, (H-CYS-OTBU)2 2 HCL can be employed in various chemical synthesis processes. Its reactivity and structural features make it a valuable component in the development of new compounds and materials with potential applications in different industries.

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 56-89-3 L-cystine 

Downstream Products

• 105729-36-0 N-(carbobenzyloxy)-S-phthalimido-L-cysteine tert-butyl ester 
• 105729-32-6 2-((R)-2-Benzyloxycarbonylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-malonic acid dimethyl ester 
• 105729-46-2 (Z)-(S)-2-((R)-2-Benzyloxycarbonylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-5-hydroxy-hex-2-enoic acid methyl ester 
• 105729-45-1 (Z)-(S)-2-((R)-2-Benzyloxycarbonylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-5-(tert-butyl-dimethyl-silanyloxy)-hex-2-enoic acid methyl ester 
• 105729-44-0 (S)-2-((R)-2-Benzyloxycarbonylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-hexanoic acid methyl ester 
• 105729-38-2 (S)-2-((R)-2-Benzyloxycarbonylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-hexanoic acid methyl ester 
• 105729-37-1 (S)-2-((R)-2-Benzyloxycarbonylamino-2-tert-butoxycarbonyl-ethylsulfanyl)-3-oxo-5-(tetrahydro-pyran-2-yloxy)-hexanoic acid methyl ester 
• 5545-17-5 N,N'-diacetyl-L-cystine 
• 98330-15-5 tert-butyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-sulfanylpropanoate 
• 1584648-47-4 (R)-tert-butyl 2-((tert-butoxycarbonyl)amino)-3-(((2S,3R)-6,6,6-trifluoro-3-(((S)-5-(3-fluorophenyl)-9-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)thio)propanoate 
• 1584647-90-4 tert-butyl S-(((2S,3R)-6,6,6-trifluoro-3-(((3S)-5-(3-fluorophenyl)-9-methyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)carbamoyl)-2-(3,3,3-trifluoropropyl)hexanoyl)amino)-L-cysteinate 
• 1079950-07-4 N,N’-diacetyl-di-tert-butyl-L-cystine 
• 142823-95-8 (R)-2-(Benzhydrylidene-amino)-3-(2,5-dioxo-pyrrolidin-1-ylsulfanyl)-propionic acid tert-butyl ester 
• 142823-92-5 (R)-2-(Benzhydrylidene-amino)-3-mercapto-propionic acid tert-butyl ester 

Relevant articles and documents

Zinc Complexes of Amino Acids and Peptides, 4 . - Zinc Complexes of Peptides with C-terminal Cysteine

The cysteine derivatives N-Ac-Cys, N-Ac-Gly-Cys, N-Ac-Ala-Cys, and N-Ac-Gly-Gly-Cys with unprotected SH and CO2H functions (LH2) were prepared by the mixed anhydride method.Their reactions with basic zinc carbonate resulted in the formation of complexes Zn(LH)2 which were converted by KOH to complexes K2.Potentiometric titrations revealed ZnL and (2-) as the major solution species.By pD-dependent NMR measurements (1H, 13C) in D2O carboxylate coordination in acidic solution and carboxylate and thiolate coordination in neutral and basic solution was identified. - Key Words: Cysteine derivatives / Zinc complexes / Solution equilibria