383-64-2 Usage
Description
S-Ethyl trifluorothioacetate is a clear colorless to slightly yellow liquid that is known for its ability to selectively trifluoroacetylate amino groups in proteins. This unique property makes it a valuable compound in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
S-Ethyl trifluorothioacetate is used as a reagent for the selective trifluoroacetylation of amino groups in proteins. This process is crucial for the modification and stabilization of proteins, which can lead to improved pharmaceutical compounds and drug candidates.
Used in Biochemical Research:
In the field of biochemical research, S-Ethyl trifluorothioacetate serves as a valuable tool for the study of protein structure and function. By selectively modifying amino groups, researchers can gain insights into the role of specific amino acid residues in protein interactions and activities.
Used in Chemical Synthesis:
S-Ethyl trifluorothioacetate is also utilized in chemical synthesis, particularly in the preparation of various organic compounds and pharmaceutical intermediates. Its ability to selectively modify amino groups makes it a versatile building block for the development of new molecules with potential applications in various industries.
Used in Analytical Chemistry:
In analytical chemistry, S-Ethyl trifluorothioacetate can be employed for the detection and quantification of amino groups in proteins and other biomolecules. This selective modification can help researchers identify and analyze specific components within complex biological samples.
Overall, S-Ethyl trifluorothioacetate is a versatile compound with a wide range of applications in various industries, including pharmaceuticals, biochemical research, chemical synthesis, and analytical chemistry. Its unique ability to selectively modify amino groups in proteins makes it a valuable tool for both research and development purposes.
Synthesis Reference(s)
Journal of the American Chemical Society, 74, p. 4005, 1952 DOI: 10.1021/ja01136a010
Purification Methods
If IR is free of OH bands then fractionally distil it; otherwise dilute the thio-ester with dry Et2O, wash with 5% KOH and H2O, dry over MgSO4 and fractionate it through an efficient column [Hauptschein et al. J Am Chem Soc 74 4005 1952]. [Beilstein 2 IV 567.] Powerful obnoxious odour.
Check Digit Verification of cas no
The CAS Registry Mumber 383-64-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,8 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 383-64:
(5*3)+(4*8)+(3*3)+(2*6)+(1*4)=72
72 % 10 = 2
So 383-64-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H5F3OS/c1-2-9-3(8)4(5,6)7/h2H2,1H3
