38309-89-6

Basic information

• Product Name: 2,7-BIS(BROMOMETHYL)NAPHTHALENE
• Synonyms: 2,7-Bis(bromomethyl)naphthalene;2,7-Bis(bromomethyl)naphthalene >=97.0% (HPLC)
• CAS NO: 38309-89-6
• Molecular Formula: C₁₂H₁₀Br₂
• Molecular Weight: 314.02
• Product Categories: Aryl;C9 to C12;Halogenated Hydrocarbons
• Mol File: 38309-89-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 146-150 °C
• Boiling Point: 386.3 °C at 760 mmHg
• Flash Point: 219.2 °C
• Appearance: /
• Density: 1.72 g/cm³
• Vapor Pressure: 7.95E-06mmHg at 25°C
• Refractive Index: 1.685
• CAS DataBase Reference: 2,7-BIS(BROMOMETHYL)NAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-BIS(BROMOMETHYL)NAPHTHALENE(38309-89-6)
• EPA Substance Registry System: 2,7-BIS(BROMOMETHYL)NAPHTHALENE(38309-89-6)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53
• Safety Statements: 26-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• F: 19
• Hazardous Substances Data: 38309-89-6(Hazardous Substances Data)

Usage

Description

2,7-BIS(BROMOMETHYL)NAPHTHALENE, also known as 2,7-bis(bromomethyl)naphthalene, is an organic compound with the molecular formula C14H10Br2. It is a white crystalline solid that is used as a chemical intermediate in the synthesis of various compounds. Its structure features a naphthalene core with two bromine atoms and two methyl groups attached to the 2 and 7 positions.

Uses

Used in Catalyst Synthesis:
2,7-BIS(BROMOMETHYL)NAPHTHALENE is used as a precursor for the synthesis of a catalyst, specifically O,O′-Diallyl-N,N′-(2,7-naphthalindiyldimethyl)-bis-(hydrocinchonidinium) dibromide. This catalyst is employed in various chemical reactions to improve their efficiency and selectivity.
Used in Chemical Intermediates:
2,7-BIS(BROMOMETHYL)NAPHTHALENE serves as a valuable chemical intermediate for the production of other organic compounds, such as dyes, pharmaceuticals, and agrochemicals. Its unique structure allows for further functionalization and modification to create a wide range of products with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,7-BIS(BROMOMETHYL)NAPHTHALENE is used as a building block for the development of novel drug candidates. Its structural properties make it a suitable candidate for the synthesis of complex molecules with potential therapeutic applications.
Used in Dye Manufacturing:
2,7-BIS(BROMOMETHYL)NAPHTHALENE is used as a starting material in the manufacturing of dyes, particularly those with specific color properties and stability. Its bromine-containing structure allows for the creation of dyes with enhanced performance characteristics.
Used in Agrochemicals:
In the agrochemical industry, 2,7-BIS(BROMOMETHYL)NAPHTHALENE is utilized as a precursor for the synthesis of various agrochemicals, such as pesticides and herbicides. Its unique chemical properties enable the development of more effective and targeted products for agricultural applications.

InChI:InChI=1/C12H10Br2/c13-7-9-1-3-11-4-2-10(8-14)6-12(11)5-9/h1-6H,7-8H2

Upstream product

• 582-16-1 2,7-dimethylnaphthalene 
• 582-17-2 2,7-Dihydroxynaphthalene 
• 151391-00-3 methanesulfonic acid 1,1,1-trifluoro-1,1'-(2,7-naphthalenedidyl) ester 

Downstream Products

• 7130-24-7 1,4-di-(2,7)naphtha-cyclohexane 
• 62764-26-5 1,2-bis-(7-methyl-[2]naphthyl)-ethane 
• 41784-92-3 (2,7-naphthylenedimethylene)bis[triphenylphosphonium bromide] 
• 54031-08-2 2,7-Bis-(m-methylstyryl)-naphthalin 
• 54031-09-3 2,7-Bis-(m-methylstyryl)-naphthalin 
• 54031-10-6 2,7-Bis-(m-methylstyryl)-naphthalin 
• 19800-49-8 2,7-naphthalenedicarboxaldehyde 
• 480427-57-4 2,7-bis[O(9)-allylhydrocinchonidinium-N-methyl]naphthalene dibromide 
• 480427-57-4 2,7-bis[O(9)-allylhydrocinchoninium-N-methyl]naphthalene dibromide 
• 852540-88-6 (7-benzenesulfonylmethyl-naphthalen-2-ylmethoxy)-tert-butyl-dimethyl-silane 
• 852540-93-3 7-{5-[3-(3-amino-propyl)-phenyl]-2-oxo-pentyl}-naphthalene-2-carboxylic acid 
• 852541-12-9 (3-{3-[5-(7-hydroxymethyl-naphthalen-2-yl)-4-oxo-pentyl]-phenyl}-propyl)-carbamic acid tert-butyl ester 
• 852540-92-2 7-{5-[3-(3-tert-butoxycarbonylamino-propyl)-phenyl]-2-oxo-pentyl}-naphthalene-2-carboxylic acid 
• 852540-91-1 [3-(3-{5-[7-(tert-butyl-dimethyl-silanyloxymethyl)-naphthalen-2-yl]-4-oxo-pentyl}-phenyl)-propyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

A bis-urea naphthalene macrocycle displaying two crystal structures with parallel ureas

Herein we synthesized a bis-urea macrocycle from 2,7-dimethylnaphthalene that displays an unusual parallel urea conformation. The naphthalenes also adopt a bowl shape over the anticipated parallel planar orientation. Crystallization of the macrocycle from different solvent systems affords two solvated forms. 1·DMSO·(H2O)2 has an extended columnar structure where parallel macrocycles are linked by intervening hydrogen bonded water molecules. In 1·(MeOH)2 direct hydrogen-bonds link the macrocycles into chains, which hydrogen-bond with methanol molecules to form a layered structure.

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formula (I), (Ia), (Ib), (II) or (III), salts thereof, pharmaceutical compositions thereof, as well as therapeutic methods of treatment and prevention.

Distance between Metal Centres Affects Catalytic Efficiency of Dinuclear CoIII Complexes in the Hydrolysis of a Phosphate Diester

Dinuclear CoIII complex catalysed hydrolysis of bis-p-nitrophenylphosphate, a DNA model substrate, is reported. The catalysts were designed in such a way that the two CoIII ions cannot be contemporaneously involved in the complexation of the substrate or transition state. Experimental evidence of the involvement of such a remote metal centre in the catalysis of the hydrolysis of a phosphate diester is provided. This contribution amounts to a ca. 64-fold rate acceleration for the second-order rate constants of the best dinuclear complex over the mononuclear one, which is apparently due to general acid or H-bonding catalysis. Furthermore, there is significant distance dependence for this catalytic contribution and, in this case, it appears that the best distance (as estimated by DFT calculations) is ca. 7.7 ?. This may indicate that the presence of metal centres in close proximity, as required for mechanism proposals in which all metals are directly involved in transition-state coordination, is not the only option for rate acceleration in natural phosphate hydrolysis.

Bis-styrylnaphthalene and bis-styrylnaphthyridine derivatives with high binding affinity to ?2-amyloid fibrils

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