383175-97-1Relevant articles and documents
Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-α-induced VCAM-1 expression
Meng, Charles Q.,Zheng, X. Sharon,Ni, Liming,Ye, Zhihong,Simpson, Jacob E.,Worsencroft, Kimberly J.,Hotema, Martha R.,Weingarten, M. David,Skudlarek, Jason W.,Gilmore, Joshua M.,Hoong, Lee K.,Hill, Russell R.,Marino, Elaine M.,Suen, Ki-Ling,Kunsch, Charles,Wasserman, Martin A.,Sikorski, James A.
, p. 1513 - 1517 (2004)
Novel chalcone derivatives have been discovered as potent inhibitors of TNF-α-induced VCAM-1 expression. Thienyl or benzothienyl substitution at the meta-position of ring B helps boost potency while large substitution at the para-position on ring B is detrimental. Various substitutions are tolerated on ring A. A lipophilicity-potency relationship has been observed in several sub-series of compounds.
1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF
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Page/Page column 169-171, (2010/02/15)
The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula (I), or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.
1, 3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders
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, (2008/06/13)
It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorder
