38320-58-0Relevant articles and documents
-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
Aksenov, Alexander V.,Aksenov, Dmitrii A.,Aksenov, nicolai A.,Arutiunov, nikolai A.,Betancourt, Tania,Du, Liqin,Grishin, Igor Yu.,Kirilov, nikita K.,Kornienko, Alexander,Rubin, Michael,Wang, Huifen,pelly, Stephen C.
, p. 7234 - 7245 (2021/08/30)
Indolizines and pyrazolo[1,5-a]pyridines were prepared via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of cancer cells. Indolizine 9db showed higher potency than that of all-trans-retinoic acid, an approved cancer drug. Mechanistically, it was found to inhibit tubulin polymerization and it is thus proposed that the discovered chemistry can be exploited for the development of novel microtubule-targeting anticancer agents.
The first approach to the synthesis of 1-unsubstituted 2- arylindolizines by intramolecular 1,5-dipolar cyclization of 2-(2- arylethenyl)pyridinium ylides in the presence of tetrakis(pyridine)cobalt (II) dichromate
Zhou, Jian,Yuefei, Hu,Hongwen, Hu
, p. 166 - 170 (2007/10/03)
The first approach to the preparation of 1-unsubstituted 2- arylindolizines by intramolecular 1,5-dipolar cyclization of 2-(2- arylethenyl)pyridinium ylides 2a-v in the presence of tetrakis(pyridine)cobalt (II) dichromate was developed. Several kinds of n