38322-74-6

Basic information

• Product Name: ethyl 7-methoxy-4-oxo-chromene-2-carboxylate
• Synonyms: ethyl 7-methoxy-4-oxo-chromene-2-carboxylate
• CAS NO: 38322-74-6
• Molecular Formula: C₁₃H₁₂O₅
• Molecular Weight: 248.2314
• Mol File: 38322-74-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 381.5°Cat760mmHg
• Flash Point: 212°C
• Appearance: /
• Density: 1.284g/cm³
• Vapor Pressure: 5.06E-06mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: ethyl 7-methoxy-4-oxo-chromene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 7-methoxy-4-oxo-chromene-2-carboxylate(38322-74-6)
• EPA Substance Registry System: ethyl 7-methoxy-4-oxo-chromene-2-carboxylate(38322-74-6)

Safety Data

• Hazardous Substances Data: 38322-74-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H12O5/c1-3-17-13(15)12-7-10(14)9-5-4-8(16-2)6-11(9)18-12/h4-7H,3H2,1-2H3

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 23866-72-0 ethyl 7-hydroxy-4-oxo-4H-chromen-2-carboxylate 
• 74-88-4 methyl iodide 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 197388-36-6 [3-(4-Chloro-3-nitro-phenoxy)-propyl]-(7-methoxy-chroman-2-ylmethyl)-amine 
• 197388-32-2 (7-Methoxy-chroman-2-ylmethyl)-[3-(2-methyl-3-nitro-phenoxy)-propyl]-amine 
• 197388-38-8 2-Chloro-5-{3-[(7-methoxy-chroman-2-ylmethyl)-amino]-propoxy}-phenylamine 
• 197388-40-2 5-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-2-methyl-phenylamine 
• 197388-42-4 3-{3-[(7-Methoxy-chroman-2-ylmethyl)-amino]-propoxy}-phenylamine 
• 197388-31-1 (7-methoxy-chroman-2-ylmethyl)-(3-phenoxy-propyl)-amine 
• 197388-29-7 (7-Methoxy-chroman-2-ylmethyl)-(4-phenyl-butyl)-amine 
• 197388-27-5 (7-Methoxy-chroman-2-ylmethyl)-(3-phenyl-propyl)-amine 
• 197388-25-3 (7-Methoxy-chroman-2-ylmethyl)-phenethyl-amine 
• 197388-19-5 Benzyl-(7-methoxy-chroman-2-ylmethyl)-amine 

Relevant articles and documents

SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY

Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

SUBSTITUTED CHROMANES AND METHOD OF USE

The invention provides for compounds of formula (I), wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R" have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj?gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

Synthesis, spectroscopic characterization and X-ray structure of novel 7-methoxy-4-oxo-N-phenyl-4H-chromene-2-carboxamides

The chromone scaffold has been found to be an important tool in the drug discovery process through its relevant pharmacological activities. Chromone carboxamide derivatives synthesized within our group have shown noteworthy results as inhibitors of monoam