38329-34-9 Usage
Description
(S)-α-amino-α-phenylacetic acid hydrochloride, commonly known as L-Phenylalanine, is an essential amino acid that plays a crucial role in the synthesis of proteins and neurotransmitters within the human body. It is widely available in various food sources, including meat, fish, eggs, dairy products, and certain fruits and vegetables. L-Phenylalanine can also be consumed as a dietary supplement. This amino acid serves as a precursor to neurotransmitters such as dopamine, norepinephrine, and epinephrine, which are vital for mood regulation and stress response. Furthermore, L-Phenylalanine is a precursor to the amino acid tyrosine, which is essential for the production of thyroid hormone thyroxine and the skin pigment melanin.
Uses
Used in Pharmaceutical Industry:
L-Phenylalanine is utilized as a key component in the production of various pharmaceuticals. Its role as a precursor to important neurotransmitters makes it a valuable ingredient in formulations for the treatment of depression and attention deficit hyperactivity disorder (ADHD). By enhancing the synthesis of mood-regulating neurotransmitters, L-Phenylalanine contributes to the effectiveness of these medications.
Used in Dietary Supplements:
As an essential amino acid, L-Phenylalanine is often included in dietary supplements to support overall health and well-being. It can help individuals who may not be getting enough of this nutrient from their diet, ensuring that their bodies have the necessary building blocks for protein synthesis and neurotransmitter production.
Used in Food Industry:
L-Phenylalanine is also used in the food industry, where it serves as a flavor enhancer and additive. Its ability to improve the taste and aroma of certain products makes it a popular choice for manufacturers looking to enhance the sensory qualities of their offerings.
Used in Cosmetics Industry:
In the cosmetics industry, L-Phenylalanine is employed as a precursor to the amino acid tyrosine, which is essential for the production of melanin, the pigment responsible for skin color. By promoting melanin synthesis, L-Phenylalanine can be used in formulations that aim to improve skin tone and provide a more even complexion.
Used in Research and Development:
L-Phenylalanine is also an important compound in research and development, particularly in the fields of neuroscience and biochemistry. Its role in neurotransmitter synthesis and its involvement in various metabolic pathways make it a valuable tool for studying the underlying mechanisms of mood regulation, stress response, and other physiological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 38329-34-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,3,2 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 38329-34:
(7*3)+(6*8)+(5*3)+(4*2)+(3*9)+(2*3)+(1*4)=129
129 % 10 = 9
So 38329-34-9 is a valid CAS Registry Number.
38329-34-9Relevant articles and documents
Stereoselectivity in the salt-cocrystal products formed by phenylglycinol or phenylglycine with their respective sodium or hydrochloride salts
Brittain, Harry G.
, p. 8 - 15 (2013)
The salt and stereoselective cocrystal phenomena associated with 2-phenylglycinol and 2-phenylglycine have been studied using X-ray powder diffraction and differential scanning calorimetry. The chiral identities of the free acids and their sodium salts, or the free bases and their chloride salts, were found to play a determining role as to whether a salt-cocrystal product could or could not be formed. In particular, when cocrystallization of an enantiomerically pure basic or zwitterionic substance with its enantiomerically pure acid addition salt was attempted, a salt-cocrystal was only obtained when the absolute configuration of the two reactants is opposite. On the other hand, it has been found that no stereoselectivity in salt-cocrystal formation existed in the cocrystallization of an enantiomerically pure acidic or zwitterionic substance with its enantiomerically pure base addition salt. Copyright
Asymmetric strecker synthesis of α-arylglycines
Perez-Fuertes, Yolanda,Taylor, James E.,Tickell, David A.,Mahon, Mary F.,Bull, Steven D.,James, Tony D.
scheme or table, p. 6038 - 6047 (2011/10/08)
A practically simple three-component Strecker reaction for the asymmetric synthesis of enantiopure α-arylglycines has been developed. Addition of a range of aryl-aldehydes to a solution of sodium cyanide and (S)-1-(4- methoxyphenyl)ethylamine affords highly crystalline (S,S)-α-aminonitriles that are easily obtained in diastereomerically pure form. Heating the resultant (S,S)-α-aminonitriles in 6 M aqueous HCl at reflux resulted in cleavage of their chiral auxiliary fragments and concomitant hydrolysis of their nitrile groups to afford enantiopure (S)-α-arylglycines. The enantiopurities of these (S)-α-arylglycines were determined via derivatization of their corresponding methyl esters with 2-formylphenylboronic acid and (S)-BINOL, followed by 1H NMR spectroscopic analysis of the resultant mixtures of diastereomeric iminoboronate esters.
Chemo-enzymatic dynamic kinetic resolution of amino acid thioesters
Arosio, Dario,Caligiuri, Antonio,D'Arrigo, Paola,Pedrocchi-Fantoni, Giuseppe,Rossi, Cristina,Saraceno, Caterina,Servi, Stefano,Tessaro, Davide
, p. 1345 - 1348 (2008/09/16)
The L-forms of racemic-N-protected-β,γa,aunsaturated a-amino acid thioesters were found to be substrates for the subtilisin-catalysed hydrolysis to the corresponding acids. The D-enantiomer was continuously racemised in the presence of an organic base. The combined reactions in a biphasic system allowed the deracemisation of the amino acid derivatives based on a dynamic kinetic resolution. Excellent yields and enantioselectivities were achieved.
