38365-53-6

Basic information

• Product Name: Benzene, 1-(2,2-dichlorocyclopropyl)-4-methoxy-
• CAS NO: 38365-53-6
• Molecular Formula: C10H10Cl2O
• Molecular Weight: 217.095
• Mol File: 38365-53-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2,2-dichlorocyclopropyl)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2,2-dichlorocyclopropyl)-4-methoxy-(38365-53-6)
• EPA Substance Registry System: Benzene, 1-(2,2-dichlorocyclopropyl)-4-methoxy-(38365-53-6)

Safety Data

• Hazardous Substances Data: 38365-53-6(Hazardous Substances Data)

Upstream product

• 637-69-4 4-Methoxystyrene 
• 3294-58-4 phenyl(bromodichloromethyl)mercury 
• 67-66-3 chloroform 

Downstream Products

• 52179-26-7 (-)-4-(2,2-dichlorocyclopropyl)phenol 
• 4030-17-5 4-methoxyphenylcyclopropane 
• 74386-98-4 p-Methoxy-(trans-2-chlorocyclopropyl)benzene 
• 74386-98-4 p-Methoxy-(cis-2-chlorocyclopropyl)benzene 
• 74387-10-3 4-(2,2-Dichloro-cyclopropyl)-2-nitro-phenol 
• 74387-03-4 4-(2,2-Dichloro-cyclopropyl)-1-methoxy-2-nitro-benzene 
• 53104-41-9 3,5-dinitro-4-methoxybenzaldehyde 
• 85365-92-0 3,5-dinitro-4-methoxybenzoic acid 
• 25755-91-3 5-chloro-3-(4-methoxyphenyl)isoxazole 

Relevant articles and documents

Synthesis of gem-Dichlorocyclopropanes Using Liquid–Liquid Slug Flow

By analyzing the causes of precipitation and clogging in continuous flow dichlorocyclopropanation, we established that the flow reaction can be performed only with T-junctions and microtubes. Unlike tertiary amines, when quaternary ammonium salts were used as PTCs, precipitation and clogging in microchannels did not occur, and an excellent yield of up to 99% was obtained after optimizing the reaction temperature, reactant concentration, and retention time. In the scale-up experiment, the reaction yields slightly decreased as the inner diameter (ID) of the microchannel was increased, but the calculated throughput increased from 2.41 g/h (ID: 1.5 mm) to 3.46 g/h (ID: 1.9 mm) and 5.13 g/h (ID: 2.4 mm).

Ionic liquids accelerating cycloaddition between 1-aryl-2-halocyclopropenes and furan

Treatment of a series of 1-aryl-2,2-dihalocyclopropanes with t-BuOK at-10 °C gave the corresponding 1-aryl-2-halocyclopropenes, which react with furan in a RTIL to give a fair good yield of the [4+2]-cycloadducts with more than 90% of the exo-isomer. The imidazolium type ionic liquids are able to accelerate this cycloaddition process with high steric selectivity. Neither pyrrole nor thiophene undergoes the cycloaddition with cyclopropene to form the [4+2]-cycloadduct. 1-Aryl-3,3-difluoro-2-halocyclopropenes are inert towards furan even at a temperature higher than 100 °C.

EFFECT OF THE NATURE OF SUBSTITUENTS IN THE THREE-CARBON RING ON THE DEMETHYLATION OF p-CYCLOPROPYLANISOLES DURING NITRATION

The behavior of a series of p-cyclopropylanisoles substituted in the small ring was investigated under conditions favoring their demethylation during nitration.It was shown that the yields of the nitrophenols which form depend on the nature and on the pos