383665-96-1

Basic information

• Product Name: (E)-3-[4-(tert-butoxycarbonylaminomethyl)phenyl]acrylic acid ethyl ester
• Synonyms: (E)-3-[4-(tert-butoxycarbonylaminomethyl)phenyl]acrylic acid ethyl ester
• CAS NO: 383665-96-1
• Molecular Weight: 305.374
• Mol File: 383665-96-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-3-[4-(tert-butoxycarbonylaminomethyl)phenyl]acrylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-[4-(tert-butoxycarbonylaminomethyl)phenyl]acrylic acid ethyl ester(383665-96-1)
• EPA Substance Registry System: (E)-3-[4-(tert-butoxycarbonylaminomethyl)phenyl]acrylic acid ethyl ester(383665-96-1)

Safety Data

• Hazardous Substances Data: 383665-96-1(Hazardous Substances Data)

Upstream product

• 68819-84-1 tert-butyl N-(4-bromobenzyl)carbamate 
• 140-88-5 ethyl acrylate 
• 3959-07-7 4-Bromobenzylamine 
• 153171-22-3 2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione 
• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 1616590-16-9 (4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide 
• 1616590-38-5 (E)-3-[4-(4,4-dimethyl-3,4-dihydrocarbostyril-6-carbonyl)aminomethylphenyl]acrylic acid ethyl ester 

Relevant articles and documents

Design and synthesis of novel and highly-active pan-histone deacetylase (pan-HDAC) inhibitors

Histone deacetylase (HDAC) inhibitions are known to elicit anticancer effects. We designed and synthesized several HDAC inhibitors. Among these compounds, compound 40 exhibited a more than 10-fold stronger inhibitory activity compared with that of suberoylanilide hydroxamic acid (SAHA) against each human HDAC isozyme in vitro (IC50 values of 40: HDAC1, 0.0038 μM; HDAC2, 0.0082 μM; HDAC3, 0.015 μM; HDAC8, 0.0060 μM; HDAC4, 0.058 μM; HDAC9, 0.0052 μM; HDAC6, 0.058 μM). The dose of the administered HDAC inhibitors that contain hydroxamic acid as the zinc-binding group may be reduced by 40. Because the carbostyril subunit is a time-tested structural component of drugs and biologically active compounds, 40 most likely exhibits good absorption, distribution, metabolism, excretion, and toxicity (ADMET). Thus, compound 40 is expected to be a promising therapeutic agent or chemical tool for the investigation of life process.