38367-22-5

Basic information

• Product Name: N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide
• Synonyms: 1-Piperidineacetamide, N-(4-nitrophenyl)-; N-(4-Nitrophenyl)-2-(piperidin-1-yl)acetamide
• CAS NO: 38367-22-5
• Molecular Formula: C₁₃H₁₇N₃O₃
• Molecular Weight: 263.2924
• Mol File: 38367-22-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 475.8°C at 760 mmHg
• Flash Point: 241.6°C
• Density: 1.266g/cm³
• Vapor Pressure: 3.21E-09mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide(38367-22-5)
• EPA Substance Registry System: N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide(38367-22-5)

Safety Data

• Hazardous Substances Data: 38367-22-5(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 17329-87-2 2-chloro-N-(4-nitro-phenyl)-acetamide 
• 50618-83-2 2-(1-piperidinyl)acetyl chloride 
• 100-01-6 4-nitro-aniline 
• 3235-67-4 piperidinoacetic acid 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 58784-04-6 1-methyl-1-[(4-nitro-phenylcarbamoyl)-methyl]-piperidinium; iodide 
• 100450-98-4 N-(4-amino-phenyl)-2-(piperidin-1-yl)-acetamide 
• 81112-62-1 N-(4-Nitro-phenyl)-2-piperidin-1-yl-acetamide; compound with oxalic acid 
• 921201-88-9 N-(4-azido-phenyl)-2-(piperidin-1-yl)-acetamide 
• 1446421-01-7 N-(4-(3-(4-(bis(2-chloroethyl)amino)phenyl)ureido)phenyl)-2-(piperidin-1-yl)acetamide 
• 1622093-63-3 N-(4-(4-((4-(1H-phenanthro[9,10-d]imidazol-2-yl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)phenyl)-2-(piperidin-1-yl)acetamide 

Relevant articles and documents

Design and synthesis of potent antitumor water-soluble phenyl N-mustard-benzenealkylamide conjugates via a bioisostere approach

A series of new, water-soluble phenyl N-mustard-benzenealkylamide conjugates containing hydrophilic ω-dialkylaminoalkylamide or ω-cyclic aminoalkylamide moieties were synthesized via a bioisostere approach. These compounds have a broad spectrum of antitumor activity against a panel of human tumor cell lines. Of these derivatives, compound 18b effectively suppressed the growth of colon cancer (HCT-116), prostate cancer (PC3), and lung cancer (H460) xenografts. The growth of HCT-116 xenografts was almost completely suppressed when co-treated with compound 18b and 5-fluorouracil. Furthermore, compound 18b can induce DNA cross-linking and cell-cycle arrest at the G2/M phase. Early preclinical studies, including pharmacokinetics in rats, inhibition of the hERG, and 14 days of acute intravenous injection toxicity, suggest that compound 18b is a promising candidate for further preclinical studies.

Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.

COMPOUNDS

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