383861-22-1

Basic information

• Product Name: 4-(5'-INDOLE)PIPERIDINE
• Synonyms: 5-Piperidin-4-yl-1H-indole
• CAS NO: 383861-22-1
• Molecular Formula: C13H16N2
• Molecular Weight: 200.28
• Mol File: 383861-22-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 388.6 °C at 760 mmHg
• Flash Point: 188.8 °C
• Appearance: /
• Density: 1.118 g/cm³
• Vapor Pressure: 3.03E-06mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(5'-INDOLE)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5'-INDOLE)PIPERIDINE(383861-22-1)
• EPA Substance Registry System: 4-(5'-INDOLE)PIPERIDINE(383861-22-1)

Safety Data

• Hazardous Substances Data: 383861-22-1(Hazardous Substances Data)

Usage

General Description

4-(5'-Indole)piperidine is a chemical compound with the molecular formula C14H18N2. It is a piperidine derivative with an indole group attached to the fourth carbon atom of the piperidine ring. 4-(5'-INDOLE)PIPERIDINE has potential pharmacological activities and is often used as a building block in medicinal chemistry for the synthesis of various biologically active compounds. It has been studied for its potential role as a dopamine receptor antagonist and has also been explored for its use in the development of new drug candidates for neurological and psychiatric disorders. Additionally, 4-(5'-Indole)piperidine has also been investigated for its potential anti-inflammatory properties and its ability to modulate immune responses.

InChI:InChI=1/C13H16N2/c1-2-13-12(5-8-15-13)9-11(1)10-3-6-14-7-4-10/h1-2,5,8-10,14-15H,3-4,6-7H2

Upstream product

• 158984-60-2 5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole 

Relevant articles and documents

NOVEL 2,3-DIHYDROINDOLE COMPOUNDS

The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are useful in the treatment of a disease where a D4 receptor and/or a 5-HT 2A receptor is implicated.

Indole derivatives useful for the treatment of CNS disorders

An indole derivative having the formula wherein a) Y1 is N, which is bound to Z, Z and Y2 are selected from CH2, CO, CS, SO and SO2; provided that at least one of Z and Y2 is CH2; Y3is O, S or CHR7and Y4is O, S or CHR8, provided that only one of Y3 and Y4 is O or S; b) Y2 is N, which is bound to Z, Z and Y1 are selected from CH2, CO, CS, SO and SO2; provided that at least one of Z and Y1 is CH2; Y3is CHR7 and Y4is O, S or CHR8; c) Y2 is N, which is bound to Z, Z and Y3 are selected from CH2, CO, CS, SO and SO2 provided that at least one of Z and Y3 is CH2; Y1 is CHR6 and Y4 is O, S or CHR8; W is a bond, O, S, CO, CS, SO or SO2; n is 0-5, m is 0-5 and n+m is 1-6; provided that when W is O or S, then n≧2 and m≧1; when W is CO, CS, SO or SO2, then n≧1 and m≧1; X is C, CH or N, provided that when X is C, the dotted line indicates a bond, and when X is N or CH, the dotted line indicates no bond; one of R1, R2, R3 and R4 forms a bond to X and the others of R1, R2, R3, R4 and R5 and R9-R12 are independently selected from hydrogen, halogen, cyano, nitro, amino, hydroxy, C1-6-alkyl-amino, di-( C1-6-alkyl )-amino, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6 alkoxy, C1-6-alkylthio, C1-6-alkyl substituted with hydroxy or thiol, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, acyl, thioacyl, trifluoromethyl, trifluoromethylsulfonyl or C1-6 alkylsulfonyl; R is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkyl substituted with hydroxy or thiol, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, acyl, thioacyl, trifluoromethylsulfonyl and C1-6 alkylsulfonyl; or pharmaceutically acceptable salts thereof. The compounds of the invention are potent dopamine D4 ligands.