384-45-2

Basic information

• Product Name: 6-fluoro-1,2-benzisothiazol-3(2H)-one-1,1-dioxide
• Synonyms: 6-fluoro-1,2-benzisothiazol-3(2H)-one-1,1-dioxide
• CAS NO: 384-45-2
• Molecular Weight: 201.178
• Mol File: 384-45-2.mol
• Article Data: 4

Chemical Properties

• Density: 1.651±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-fluoro-1,2-benzisothiazol-3(2H)-one-1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-1,2-benzisothiazol-3(2H)-one-1,1-dioxide(384-45-2)
• EPA Substance Registry System: 6-fluoro-1,2-benzisothiazol-3(2H)-one-1,1-dioxide(384-45-2)

Safety Data

• Hazardous Substances Data: 384-45-2(Hazardous Substances Data)

Usage

Derivative

Derived from benzisothiazolone

Fluorine Position

Fluorine atom at the 6 position

Usage

Used in the pharmaceutical industry
Building block for synthesizing various drugs and bioactive compounds

Biological Activities

Antiviral
Antimicrobial
Anticancer

Potential Therapeutic Applications

Treatment of neurodegenerative disorders
Treatment of inflammatory diseases

Upstream product

• 2475-81-2 methyl 4-fluoroanthranilate 
• 2339-57-3 5-fluoro-2-methylbenzenesulfonamide 
• 445-05-6 5-fluoro-2-methylbenzenesulfonyl chloride 

Downstream Products

• 612541-15-8 5-fluoro-2-cyanobenzenesulfonyl chloride 
• 612538-09-7 2-cyano-5-fluoro-N-(5-isopropyl-4-methyl-3H-thiazol-2-ylidene)-benzenesulfonamide 

Relevant articles and documents

Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) continues to spread worldwide, with 25 million confirmed cases and 800 thousand deaths. Effective treatments to target SARS-CoV-2 are urgently needed. In the present study, we have identified a

Oxidative cyclization of N-alkyl-o-methyl-arenesulfonamides to biologically important saccharin derivatives

Various biologically important saccharin skeletons and their N-alkyl derivatives have been efficiently prepared by chromium(VI) oxide catalyzed H5IO6 oxidation of N-alkyl-o-methyl-arenesulfonamides in acetonitrile. N-tert-Butyl saccharin skeletons were easily prepared by H5IO6-CrO3 oxidation of N-tert-butyl-o-methyl arenesulfonamides in the presence of acetic anhydride. The method that furnished the novel fluoro and trifluoromethyl substituted saccharin skeletons is characterized by two steps, a simple work-up procedure, a single purification and good overall yields from substituted toluene derivatives.