38462-78-1

Basic information

• Product Name: 6-Methylquinoline-2-carboxaldehyde
• Synonyms: 6-Methylquinoline-2-carboxaldehyde;6-Methyl-2-Quinolinecarboxaldehyde;6-Methyl-2-Quinolinecarboxaldehyde(WX624089)
• CAS NO: 38462-78-1
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.19526
• Mol File: 38462-78-1.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Methylquinoline-2-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methylquinoline-2-carboxaldehyde(38462-78-1)
• EPA Substance Registry System: 6-Methylquinoline-2-carboxaldehyde(38462-78-1)

Safety Data

• Hazardous Substances Data: 38462-78-1(Hazardous Substances Data)

Upstream product

• 860198-63-6 2-dibromomethyl-6-methyl-quinoline 
• 877-43-0 2,6-dimethylquinoline 
• 342424-02-6 6-methyl-2-tribromomethyl-quinoline 
• 110-88-3 1,3,5-Trioxan 
• 91-62-3 6-methylquinoline 
• 106-49-0 p-toluidine 
• 170697-87-7 2,6-dimethyl-4-ethoxy-1,2,3,4-tetrahydroquinoline 
• 67-56-1 methanol 

Downstream Products

• 15733-84-3 6-methyl-quinoline-2-carboxylic acid 
• 130161-04-5 6-methylquinoline-2-N-(p-ethoxyphenyl)formimidoyl 

Relevant articles and documents

Visible Light-Driven Decarboxylative Alkylation of Aldehydes via Electron Donor–Acceptor Complexes of Active Esters

There are some synthesis methods from widely available aldehydes to the corresponding ketones, however, they involved in multistep reactions with Grignard’s reagents or transition metal catalysts. In this paper, we have developed photocatalyst-free and visible light-driven decarboxylative alkylation of pyridinaldehydes. The photochemical reactions are initiated via photoinduced single electron transfer from triethylamine to N-hydroxyphthalimide esters in electron donor–acceptor complexes. This photochemical method can achieve to translate 15 pyridinaldehydes and 11 2-quinolinaldehydes to the corresponding ketones. Furthermore, this strategy can also achieve two other transformations, disulfanes to aryl sulfides and a styrene sulfone to the alkyl-substituted alkene.

Methanol as a formylating agent in nitrogen heterocycles

A radical mediated C-H direct formylation of N-heteroarenes with methanol is reported. The reaction features a novel iron-catalyzed Minisci oxidative coupling process using commercially available methanol as a formylating reagent. It effectively solved the long-standing problems associated with using methanol as a formylating reagent in these types of reactions. Compared to the traditional Minisci C-H formylation methods, this protocol is highly atom-economical, simple to operate, and environmentally friendly and shows good functional group tolerance. This Minisci formylation strategy is a straightforward approach for the late-stage functionalization of N-heteroarenes. This journal is

Rh-Catalyzed Formal [3+2] Cyclization for the Synthesis of 5-Aryl-2-(quinolin-2-yl)oxazoles and Its Applications in Metal Ions Probes

A facile and efficient strategy for the synthesis of 5-aryl-2-(quinolin-2-yl)oxazoles via rhodium-catalyzed formal [3+2] cyclization of 4-aryl-1-tosyl-1H-1,2,3-triazoles with quinoline-2-carbaldehydes has been described. The protocol employs mild conditions and offers good yields of diverse 2,5-aryloxazole derivatives with a broad reaction scope. It is amenable to gram-scale synthesis and easily transformation. Moreover, this 5-aryl-2-(quinolin-2-yl)oxazole skeleton is indeed a new fluorophore and its applications in metal ions probes are also investigated and showed fluorescent responses to mercury ion.