38470-28-9

Basic information

• Product Name: 8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE
• Synonyms: 8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE;8-Fluoro-2,3-dihydroquinolin-4-one 97%;8-Fluoro-2,3-dihydroquinolin-4-one97%;2,3-Dihydro-8-fluoroquinolin-4(1H)-one 97%;8-Fluoro-4-oxo-1,2,3,4-tetrahydroquinoline;8-fluoro-2,3-dihydro-1H-quinolin-4-one;8-fluoro-2,3-dihydroquinolin-4(1H)-one;2,3-Dihydro-8-fluoroquinolin-4(1H)-one97%
• CAS NO: 38470-28-9
• Molecular Formula: C₉H₈FNO
• Molecular Weight: 165.16
• Mol File: 38470-28-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 125-127
• Boiling Point: 297.7°C at 760 mmHg
• Flash Point: 133.8°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 0.00133mmHg at 25°C
• Refractive Index: 1.542
• PKA: 1.32±0.20(Predicted)
• CAS DataBase Reference: 8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE(38470-28-9)
• EPA Substance Registry System: 8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE(38470-28-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 38470-28-9(Hazardous Substances Data)

Usage

General Description

8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE is a chemical compound with a molecular formula C9H7FNO, commonly used in the pharmaceutical industry. It is a heterocyclic compound that contains a fluorine atom and a quinoline ring structure. 8-FLUORO-2,3-DIHYDROQUINOLIN-4-ONE has potential applications in medicinal chemistry, particularly in the development of new drugs and pharmaceuticals. It may exhibit pharmacological properties and biological activities that make it useful for various therapeutic purposes. Additionally, its unique structure and properties make it a promising candidate for further research and development in the field of organic chemistry and drug discovery.

InChI:InChI=1/C9H8FNO/c10-7-3-1-2-6-8(12)4-5-11-9(6)7/h1-3,11H,4-5H2

Upstream product

• 38470-19-8 3-(o-fluorophenylamino)propionic acid 
• 348-54-9 2-Fluoroaniline 

Downstream Products

• 825-22-9 3-fluoroanthranilic acid 
• 75414-02-7 8-fluoro-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

2,3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivatives as well as preparation method and application thereof

The invention discloses 2,3-dihydro-1H-quinoline-4-ketone thiosemicarbazone derivatives as well as a preparation method and application thereof. The structural formula of the derivatives is as shown in a formula (I): (the formula is as shown in the description), wherein R1 is halogen, alkyl or alkoxy; R2 is hydrogen, halogen or alkoxy; R3 is hydrogen or halogen; R4 is hydrogen or halogen; X is hydrogen, acetyl or nitryl; and Y is hydrogen or phenyl. The derivatives can obviously inhibit proliferation of tumor cells, and has significant inhibition effect on multiple cancer cell strains such asbreast cancer cells, melanoma cells and prostatic cancer cells; and the anti-tumor activity is obviously better than that of a broad-spectrum anti-cancer medicine cis-platinum. In addition, the preparation process of the derivatives is simple, the conditions are mild, the sources of the raw materials are rich, the production cost is low, and potential medicinal value and good application prospectin the aspect of preparing a novel anti-tumor medicine are achieved.

Process for the preparation of 3- and/or 5-substituted anthranilic acids

Anthranilic acids substituted in the 3- and/or 5-position are valuable intermediates for the production of agricultural chemicals. These substituted anthranilic acids can be obtained in good yield without undesirable isomeric byproducts by the oxidative r