38474-03-2

Basic information

• Product Name: Benzene, 1-methoxy-3-[(1-methylethyl)thio]-
• CAS NO: 38474-03-2
• Molecular Formula: C10H14OS
• Molecular Weight: 182.287
• Mol File: 38474-03-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-3-[(1-methylethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-3-[(1-methylethyl)thio]-(38474-03-2)
• EPA Substance Registry System: Benzene, 1-methoxy-3-[(1-methylethyl)thio]-(38474-03-2)

Safety Data

• Hazardous Substances Data: 38474-03-2(Hazardous Substances Data)

Upstream product

• 15570-12-4 3-methoxybenzenethiol 
• 75-26-3 isopropyl bromide 

Downstream Products

• 63635-23-4 2-(isopropylthio)-6-methoxybenzoic acid 
• 141819-38-7 ethyl 2-[(3-methoxyphenyl)thio]acetate 
• 1004-66-6 2-methoxy-1,3-dimethylbenzene 
• 6738-23-4 2,4-dimethylanisole 
• 2206-43-1 4-methoxyisophthalic acid 
• 1951-38-8 2-methoxyisophthalic acid 

Relevant articles and documents

Sulfonium ylide formation and subsequent C[sbnd]S bond cleavage of aromatic isopropyl sulfide catalyzed by hemin in aqueous solvent

Heme is an abundant and widely existed cofactor for a variety of metalloenzymes, whose broader use is generally impeded by its high instability and poor solubility. Here we report an environment-benign and efficient strategy for the sulfonium ylide formation and subsequent C[sbnd]S bond cleavage of aromatic isopropyl sulfides, which was catalyzed by hemin in assistance of Triton X-100. This aqueous catalytic system exhibited good functional group tolerance to a variety of sulfides and diazo esters. And the reaction mechanism was preliminarily proposed on the basis of designed reactions. Furthermore, the cleavage of C[sbnd]S bond followed by introducing a functional ester group to aromatic sulfides, may potentially be employed for the late stage functionalization (LSF) of organosulfur drug in the future.