384858-14-4

Basic information

• Product Name: N-[(4-methoxyphenyl)methyl]thiazole 2-amine
• Synonyms: N-[(4-methoxyphenyl)methyl]thiazole 2-amine
• CAS NO: 384858-14-4
• Molecular Weight: 220.295
• Mol File: 384858-14-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 147.4-148 °C
• Boiling Point: 371.5±44.0 °C(Predicted)
• Density: 1.249±0.06 g/cm3(Predicted)
• CAS DataBase Reference: N-[(4-methoxyphenyl)methyl]thiazole 2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-methoxyphenyl)methyl]thiazole 2-amine(384858-14-4)
• EPA Substance Registry System: N-[(4-methoxyphenyl)methyl]thiazole 2-amine(384858-14-4)

Safety Data

• Hazardous Substances Data: 384858-14-4(Hazardous Substances Data)

Upstream product

• 303122-55-6 4-methoxy-N-(thiazol-2-ylamino)benzoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 96-50-4 2-thiazolylamine 
• 2393-23-9 4-methoxy-benzylamine 
• 623-46-1 1,2-dichloro-2-ethoxyethane 
• 37412-64-9 1-(4-methoxybenzyl)thiourea 

Downstream Products

• 1450923-32-6 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450923-58-6 3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide 
• 1450923-98-4 C₂₇H₂₀F₄N₄O₄S₂ 
• 1450923-86-0 6-chloro-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450923-87-1 6-chloro-4-(2-cyano-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450923-89-3 6-bromo-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450923-91-7 6-bromo-4-(2-methoxy-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450923-39-3 tert-butyl 4-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1450923-40-6 N-(4-methoxybenzyl)-4-(2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethyl)phenyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450923-24-6 N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450923-60-0 4-amino-3-hydroxy-N-(4-methoxybenzyl)-N-(thiazol-2-yl)benzenesulfonamide 
• 1450922-58-3 4-(2-cyano-4-(trifluoromethyl)phenyl)-8-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450922-60-7 4-(2-cyano-4-(trifluoromethyl)phenyl)-5-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450922-57-2 4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 

Relevant articles and documents

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents

Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti-inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFα and IL-8 release with IC50 values in μM range without cytotoxic activity.

DIHYDROBENZOXAZINE AND TETRAHYDROQUINOXALINE SODIUM CHANNEL INHIBITORS

The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.

Synthesis and microbiological evaluations of (N-heteroaryl)arylmethanamines and their Schiff bases

The synthesis as well as the antimicrobial and antiviral activities of new (N-heteroaryl)arylmethanamines and their Schiff bases are reported. None of the tested compounds showed activity against Herpes simplex virus type 2 and against Gram positive and Gram negative bacteria. Weak or moderate activity on poliovirus Sabin type 1, on reverse transcriptase and against Cryptococcus neoformans was shown by some of the tested compounds. Viceversa several synthesized compounds exhibited a moderate or good activity against strains of Candida albicans, while only some of the tested compounds were found moderately active against strains of Candida sp. Instead numerous new compounds 3 or 4 were active as control against isolates of plant pathogenic fungi. The obtained results are discussed on the basis of structure-activity relationships.