38511-88-5

Basic information

• Product Name: Oxazole, 5-methyl-2,4-diphenyl-
• Synonyms: 2,4-diphenyl-5-methyloxazole;5-Methyl-2,4-diphenyl-oxazol;Oxazole,5-methyl-2,4-diphenyl;5-methyl-2,4-diphenyloxazole
• CAS NO: 38511-88-5
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Mol File: 38511-88-5.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Oxazole, 5-methyl-2,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Oxazole, 5-methyl-2,4-diphenyl-(38511-88-5)
• EPA Substance Registry System: Oxazole, 5-methyl-2,4-diphenyl-(38511-88-5)

Safety Data

• Hazardous Substances Data: 38511-88-5(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 98-88-4 benzoyl chloride 
• 93-55-0 1-phenyl-propan-1-one 
• 134-81-6 benzil 
• 50874-15-2 1-phenylprop-2-ynyl-1-amine 
• 591-50-4 iodobenzene 
• 2248-46-6 ethyl 2,2-difluoro-2-phenylacetate 
• 29548-91-2 1-phenyl-1,1-difluoropropan-2-one 
• 29548-92-3 1,1-difluoro-1-phenylpropan-2-ol 
• 100-47-0 benzonitrile 
• 23031-08-5 benzoyl(pyridin-1-ium-1-yl)amide 
• 100-46-9 benzylamine 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 780-25-6 N-benzylidene benzylamine 

Downstream Products

• 3038-14-0 1-Benzoylamino-2-methyl-1-phenylethylen 
• 65-85-0 benzoic acid 
• 100-47-0 benzonitrile 

Relevant articles and documents

Cyanide-Free Cyanation of sp2 and sp-Carbon Atoms by an Oxazole-Based Masked CN Source Using Flow Microreactors

This work reports a cyanide-free continuous-flow process for cyanation of sp2 and sp carbons to synthesize aryl, vinyl and acetylenic nitriles from (5-methyl-2-phenyloxazol-4-yl) boronic acid [OxBA] reagent as a sole source of carbon-bound mask

2. 4, 5 - Tri-substituted oxazole and its synthesis method

The application relates to a 2, 4, 5 - tri-substituted oxazole compound and its synthetic method, adopts the non-metallic iodine simple substance as the catalyst, using air or oxygen as the oxidizing agent, for pyridine, quinoline, triethylamine, NMP, DMA

Lewis acid-mediated defluorinative [3+2] cycloaddition/aromatization cascade of 2,2-difluoroethanol systems with nitriles

The properties of C?F bonds, including high thermal and chemical stability, make derivatization of organic fluorine-containing compounds by the activation of the C?F bond and subsequent functionalization quite challenging. We herein report a Lewis acid-mediated defluorinative cycloaddition/aromatization cascade of 2,2-difluoroethanols with nitriles as a novel synthetic method for the preparation of 2,4,5-trisubstituted oxazoles. This reaction, which involves cleavage of two C?F bonds and the consecutive formation of C?O and C?N bonds in a one-pot fashion, features a broad substrate scope and moderate to high reaction yields. Mechanistic studies revealed that the reaction is initiated by the Lewis acid-mediated ring closure of the 2,2-difluoroethanol to produce the fluoroepoxide intermediate. (Figure presented.).