38533-19-6

Basic information

• Product Name: 2-phenyl-2H-1,4-benzothiazin-3(4H)-one
• Synonyms: 2-phenyl-3,4-dihydro-2H-1,4-benzothiazin-3-one
• CAS NO: 38533-19-6
• Molecular Formula: C₁₄H₁₁NOS
• Molecular Weight: 241.3082
• Mol File: 38533-19-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 452.7°C at 760 mmHg
• Flash Point: 227.6°C
• Density: 1.253g/cm³
• Vapor Pressure: 2.19E-08mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 2-phenyl-2H-1,4-benzothiazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-2H-1,4-benzothiazin-3(4H)-one(38533-19-6)
• EPA Substance Registry System: 2-phenyl-2H-1,4-benzothiazin-3(4H)-one(38533-19-6)

Safety Data

• Hazardous Substances Data: 38533-19-6(Hazardous Substances Data)

Usage

General Description

2-phenyl-2H-1,4-benzothiazin-3(4H)-one, also known as BTZ, is a chemical compound with the molecular formula C14H17NO2S. It is a synthetic derivative of benzothiazinone and has been studied for its potential as an anti-tuberculosis drug. BTZ has shown promising inhibitory activity against Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. Research has also found that BTZ can effectively inhibit the growth of both drug-susceptible and drug-resistant strains of tuberculosis. Its mechanism of action involves blocking the biosynthesis of the mycobacterial cell wall, making it a potential candidate for the development of new tuberculosis treatments.

Upstream product

• 4870-65-9 2-bromophenylacetic acid 
• 137-07-5 2-amino-benzenethiol 
• 37128-01-1 2-chloro-N-(2-methylsulfanyl-phenyl)-2-phenyl-acetamide 
• 2000-43-3 2,2,2-trichloro-1-phenylethanol 
• 14191-98-1 2-acetoxy-4H-benzo[1,4]thiazin-3-one 
• 71-43-2 benzene 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 4755-72-0 Chloro-phenyl-acetic acid 
• 101-41-7 benzeneacetic acid methyl ester 
• 1141-88-4 2-Aminophenyl disulfide 
• 21201-23-0 4-acetoxy-4H-benzo[1,4]thiazin-3-one 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 2912-62-1 α-chlorophenylacetyl chloride 

Downstream Products

• 96973-30-7 4-(2-morpholin-4-yl-ethyl)-2-phenyl-4H-benzo[1,4]thiazin-3-one 
• 95948-81-5 2-phenyl-4-(2-piperidin-1-yl-ethyl)-4H-benzo[1,4]thiazin-3-one 
• 97018-09-2 4-(2-diethylamino-propyl)-2-phenyl-4H-benzo[1,4]thiazin-3-one 
• 30015-70-4 4-benzyl-2-phenyl-2,3-dihydro-4H-benzothiazin-3-one 
• 95277-50-2 4-(2-dimethylamino-propyl)-2-phenyl-4H-benzo[1,4]thiazin-3-one 
• 94067-49-9 4-(2-dimethylamino-ethyl)-2-phenyl-4H-benzo[1,4]thiazin-3-one 
• 4771-95-3 4-(2-diethylamino-ethyl)-2-phenyl-4H-benzo[1,4]thiazin-3-one 
• 30015-69-1 4-methyl-2-phenyl-2H-1,4-benzothiazine-⁽³⁾-one 
• 93301-17-8 2-methyl-2-phenyl-3-oxo-2,3-dihydro-4H-1,4-benzothiazine 
• 83523-72-2 2-phenyl-3,4-dihydro-1,4-(2H)-benzothiazine 
• 58553-41-6 2-phenyl-2,3-dihydro-1,4-benzothiazine-3-thione 
• 333323-65-2 N-(2,2-dimethoxyethyl)-2-phenyl-2,3-dihydro-4H-benzo[1,4]thiazin-3-one 
• 333323-69-6 (3-oxo-2-phenyl-2,3-dihydrobenzo[1,4]thiazin-4-yl)-acetaldehyde 
• 78600-49-4 4-acetyl-2-acetoxymethyl-2-phenyl-2,3-dihydro-4H-1,4-benzothiazine 

Relevant articles and documents

Enhancing the Extent of Enolization for α-C-H Bonds of Aliphatic Carboxylic Acid Equivalents via Ion Pair Catalysis: Application toward α-Chalcogenation

In general, the α-functionalization of carboxylic acid derivatives requires either a transition metal catalyst or a stoichiometric activating agent/strong base/external additive. A transition metal free α-chalcogenation of aliphatic carboxylic acid equivalents is reported herein via ion pair formation using K3PO4 as a catalyst. Mild conditions, broad scope, scalability of the process, attaining bioactive glucokinase activators, and some synthetic intermediates establish merits of the strategy.

DABCO mediated one pot synthesis of sulfoxonium ylides under blue LED

DABCO mediated practical and convenient one pot method has been developed to access sulfoxonium ylides under photoredox and metal free conditions at room temperature. The protocol explored the reactivity of DMSO and α-aryl-α-diazo esters in presence of DABCO under blue LED condition. We demonstrated the generality of this protocol by synthesizing a variety of sulfoxonium ylides in very good yields. The practicality of the protocol has been demonstrated by the gram scale synthesis as well as by the extension of this protocol to synthesize precursors of biologically active compounds. This straightforward and practical method offers an alternative route to access very useful sulfoxonium ylides from α-aryl-α-diazoacetates.

LXR modulators

A compound of formula I wherein A, X, q, R1, R2a, R2b, R2c, R3a, and R3b are defined herein.