38558-75-7

Basic information

• Product Name: 3-hydroxy-2,5-diphenyl-[1,4]benzoquinone
• CAS NO: 38558-75-7
• Molecular Weight: 276.291
• Mol File: 38558-75-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-2,5-diphenyl-[1,4]benzoquinone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-2,5-diphenyl-[1,4]benzoquinone(38558-75-7)
• EPA Substance Registry System: 3-hydroxy-2,5-diphenyl-[1,4]benzoquinone(38558-75-7)

Safety Data

• Hazardous Substances Data: 38558-75-7(Hazardous Substances Data)

Upstream product

• 548-59-4 2,5-dihydroxy-3,6-diphenyl-1,4-benzoquinone 

Relevant articles and documents

The coupled reaction catalyzed by EchB and EchC lead to the formation of the common 2′,3′,5′-trihydroxy-benzene core in echosides biosynthesis

p-Terphenyls represent a unique family of aromatic natural products generated by nonribosomal peptide synthetase-like (NRPS-like) enzyme. After formation of p-terphenyl skeleton, tailoring modifications will give rise to structural diversity and various biological activities. Here we demonstrated a two-enzyme (EchB, a short-chain dehydrogenase/reductase (SDR), and EchC, a nuclear transport factor 2 (NTF2)-like dehydratase) participated transformation from dihydroxybenzoquinone core to 2′,3′,5′-trihydroxy-benzene in the biosynthesis of echosides. Beginning with polyporic acid as substrate, successive steps of reduction-dehydration-reduction cascade catalyzed by EchB-EchC-EchB were concluded after in vivo gene disruption and in vitro bioassay experiments. These findings demonstrated a conserved synthesis pathway of 2′,3′,5′-trihydroxy-p-terphenyls in bacteria, such as Actinomycetes and Burkholderia. The parallel pathway in fungi has yet to be explored.