38559-35-2

Basic information

• Product Name: 3,10-dimethyl-5-deazaisoalloxazine
• Synonyms: 3,10-dimethyl-5-deazaisoalloxazine;3,10-Dimethylpyrimido[4,5-b]1,2-dihydroquinolin-2,4-dione
• CAS NO: 38559-35-2
• Molecular Formula: C₁₃H₁₁N₃O₂
• Molecular Weight: 241.24534
• Mol File: 38559-35-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 377°Cat760mmHg
• Flash Point: 181.8°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 6.94E-06mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 3,10-dimethyl-5-deazaisoalloxazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,10-dimethyl-5-deazaisoalloxazine(38559-35-2)
• EPA Substance Registry System: 3,10-dimethyl-5-deazaisoalloxazine(38559-35-2)

Safety Data

• Hazardous Substances Data: 38559-35-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H11N3O2/c1-15-10-6-4-3-5-8(10)7-9-11(15)14-13(18)16(2)12(9)17/h3-7H,1-2H3

Upstream product

• 948-43-6 N-methylacridinium iodide 
• 64630-12-2 dihyrodeazaflavin 
• 13076-43-2 3-(aminocarbonyl)-1-benzylpyridinium bromide 
• 6516-41-2 1-benzyl-3-(methoxycarbonyl)pyridinium bromide 
• 98576-69-3 1-methyl-3-(N-benzylcarbamoyl)pyridinium iodide 
• 5412-06-6 N-methyl phenanthridinium iodide 
• 70083-49-7 N-benzyl-3-cyanoquinolinium bromide 
• 6516-53-6 N-benzyl-3-cyanopyridin-1-ium bromide 
• 75444-92-7 C₁₉H₂₂N₆O₄ 
• 64433-61-0 5-benzylphenanthridin-5-ium bromide 
• 87861-99-2 5-(4-Trifluoromethyl-benzyl)-phenanthridinium; bromide 
• 87861-96-9 3-Cyano-1-(4-trifluoromethyl-benzyl)-quinolinium; bromide 
• 13367-81-2 10-methylacridinium cation 
• 64630-12-2 1,5-Dihydro-3,10-dimethyl-pyrimido<4,5-b>chinolin-2,4(3H,10H)-dion 

Downstream Products

• 5412-06-6 N-methyl phenanthridinium iodide 
• 64630-12-2 dihyrodeazaflavin 
• 13076-43-2 3-(aminocarbonyl)-1-benzylpyridinium bromide 
• 6516-41-2 1-benzyl-3-(methoxycarbonyl)pyridinium bromide 
• 70083-49-7 N-benzyl-3-cyanoquinolinium bromide 
• 6516-53-6 N-benzyl-3-cyanopyridin-1-ium bromide 
• 98576-69-3 1-methyl-3-(N-benzylcarbamoyl)pyridinium iodide 
• 948-43-6 N-methylacridinium iodide 
• 64433-61-0 5-benzylphenanthridin-5-ium bromide 
• 87861-99-2 5-(4-Trifluoromethyl-benzyl)-phenanthridinium; bromide 
• 87861-96-9 3-Cyano-1-(4-trifluoromethyl-benzyl)-quinolinium; bromide 
• 67984-94-5 1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 
• 67984-92-3 3,10-Dimethyl-1,5-dihydro-2,4,5(1H,3H,5H,10H)-pyrimido<4,5-b>chinolintrion 
• 129554-89-8 1,5-Dihydro-3,10-dimethyl-5-phenyl-pyrimido<4,5-b>chinolin-2,4(3H,10H)-dion 

Relevant articles and documents

Marcus Theory of Hydride Transfer from an Anionic reduced Deazaflavin to NAD+ Analogues

Eighteen rate constants, kij for hydride transfer from the conjugate base of 1,5-dihydro-3,10-dimethyl-5-diazaisoalloxazine to a variety of pyridinium, quinolinium, phenanthridinium, and acridinium ions have been determined. (All the oxidizing agents can be regarded as analogues of NAD+.) The kij values span 7 powers of 10 and the corresponding equilibrium constants, Kij, span more than 13 powers of 10.For reactions with ΔG0 near zero, the kij values are close to those given by modified Marcus theory (ref 10).However, with more negative ΔG0 values, the observed kij increase more strogly than the calculated values.Agreement can be produced by making the standard free energy of precursor complex formation, symbolized WT +- here, to indicate that it applies to reactants of opposite charge, a linear function of ΔG0, and treating the slope and interrcept of the linear relation as adjustable parameters.The best fit is obtained with WT+-(in kJ*mol-1)=-9.4+0.11ΔG0.An avarage discrepancy between calculated and observed ln kij values of 0.5 is achieved, which is a good as the overall fit achieved for hydride transfer from neutral NADH analogues to NAD+ analogues (ref 10).The form and the parameterization of Wf are shown to be a physically reasonable approximation for reactions with ΔG00.These results strengthen the conclusion (ref 10) that a wide range of hydride transfer rates can be quantitavely understood without introducing high-energy metastable intermediates (radicals and radical ions).

A Novel Synthesis of Pyrimidoquinoline-2(3H),4(10H)-diones (5-Deazaflavins) and Analogues by the Oxidative Cyclization of 5,5'-Arylmethylenebis-(6-alkylamino-3-methyluracils)

The oxidative coupling of 5,5'-arylmethylenebis-(6-alkylamino-3-methyluracils), prepared by the condensation of 6-alkylamino-3-methyluracils and arenecarbaldehydes, with diethyl azodiformate afforded the corresponding pyrimidoquinoline-2(3H),4(10H)