38567-00-9

Basic information

• Product Name: 4-(2-CHLORO-ETHOXY)-BENZOIC ACID METHYL ESTER
• Synonyms: 4-(2-CHLORO-ETHOXY)-BENZOIC ACID METHYL ESTER;RARECHEM AL BF 0947
• CAS NO: 38567-00-9
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.65
• Mol File: 38567-00-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-CHLORO-ETHOXY)-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLORO-ETHOXY)-BENZOIC ACID METHYL ESTER(38567-00-9)
• EPA Substance Registry System: 4-(2-CHLORO-ETHOXY)-BENZOIC ACID METHYL ESTER(38567-00-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 38567-00-9(Hazardous Substances Data)

Usage

General Description

4-(2-chloro-ethoxy)-benzoic acid methyl ester, also known as methyl 4-(2-chloroethoxy)benzoate, is a chemical compound with the molecular formula C10H11ClO3. It is a colorless to yellow liquid that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-(2-CHLORO-ETHOXY)-BENZOIC ACID METHYL ESTER is also a key building block for the production of various ester derivatives that have potential applications in the field of organic chemistry. It is important to handle this chemical with caution, as it can be harmful if ingested, inhaled, or in contact with skin. Additionally, it may cause irritation to the eyes, skin, and respiratory system.

Upstream product

• 3204-73-7 4-(2-hydroxyethoxy)benzoic acid methyl ester 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 107-04-0 1-Bromo-2-chloroethane 
• 107-06-2 1,2-dichloro-ethane 
• 16670-48-7 2-chloroethyl benzenesulfonate 
• 64-17-5 ethanol 
• 80-41-1 2-chloroethyl tosylate 
• 1126-46-1 Methyl 4-chlorobenzoate 

Downstream Products

• 133384-30-2 methyl 4-<2-(1H-pyrazol-1-yl)-ethoxy>-benzoate 
• 75912-98-0 methyl 4-<2-(1H-imidazol-1-yl)-ethoxy>-benzoate 
• 133384-29-9 methyl 4-<2-(1H-1,2,4-triazol-1-yl)-ethoxy>-benzoate 
• 41074-02-6 4-methoxycarbonylphenyl vinyl ether 
• 133384-32-4 methyl 4-<2-(1H-pyrrol-1-yl)-ethoxy>-benzoate 
• 56850-92-1 methyl 4-(2-azidoethoxy)-benzoate 
• 133384-31-3 4-<2-(1H-pyrazol-1-yl)-ethoxy>-benzoic acid 
• 97988-29-9 4-<2-(1H-1,2,4-triazol-1-yl)-ethoxy>-benzoic acid 

Relevant articles and documents

Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator

Estrogen receptors (ERs) play a major role in the growth of human breast cancer cells. A selective estrogen receptor down-regulator (SERD) that acts as not only an inhibitor of ligand binding, but also induces the down-regulation of ER, would be useful fo

Palladium catalyzed chloroethoxylation of aromatic and heteroaromatic chlorides: An orthogonal functionalization of a chloroethoxy linker

A novel disconnection based on cross-coupling chemistry was designed to access pharmaceutically relevant aryl-aminoethyl ethers. The developed palladium-catalyzed functionalization of aryl- and heteroaryl chlorides with a sodium tetrakis-(2-chloroethoxy) borate salt is orthogonal to the simple nucleophilic replacement of the chloro function of the ethylene linker. The transformation enables efficient 2-chloroethoxylation in the absence of an additional external base. Subsequent amine substitution of the alkyl halide affords 2-aminoethoxy arenes. The applicability of this method was demonstrated through the synthesis of various aryl- and heteroaryl-alkyl ethers, including the intermediates of marketed drug molecules.

Synthesis and preliminary use of novel acrylic ester-derived task-specific ionic liquids

Novel electrophilic alkenes bearing an ionic liquid-type appendage have been prepared and used in Diels-Alder cycloadditions, 1,4-additions, Heck couplings and Stetter reactions; this new type of support allows easy monitoring of the reactions by NMR and MS as well as simple and efficient work-up and isolation procedures.