385842-97-7

Basic information

• Product Name: (S)-2-amino-N-ethoxycarbonyl-3-(4-hydroxyphenyl)-propanol
• Synonyms: (S)-2-amino-N-ethoxycarbonyl-3-(4-hydroxyphenyl)-propanol
• CAS NO: 385842-97-7
• Molecular Weight: 239.271
• Mol File: 385842-97-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-amino-N-ethoxycarbonyl-3-(4-hydroxyphenyl)-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-amino-N-ethoxycarbonyl-3-(4-hydroxyphenyl)-propanol(385842-97-7)
• EPA Substance Registry System: (S)-2-amino-N-ethoxycarbonyl-3-(4-hydroxyphenyl)-propanol(385842-97-7)

Safety Data

• Hazardous Substances Data: 385842-97-7(Hazardous Substances Data)

Upstream product

• 1080-06-4 L-Tyr-OMe 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 215596-38-6 (S)-3-(4-hydroxyphenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester 

Downstream Products

• 187332-12-3 (4S)-4-(4-hydroxybenzyl)-1,3-oxazolidin-2-one 

Relevant articles and documents

Solid supported chiral auxiliaries in asymmetric synthesis. Part 2: Catalysis of 1,3-dipolar cycloadditions by Mg(II) cation

1,3-Dipolar cycloadditions of supported Evans' chiral auxiliary with nitrile oxides and nitrones in the presence of Mg(II) cation as catalyst were evaluated. The presence of acetonitrile as co-solvent was found to be fundamental for the Lewis acid catalysis on solid-phase. The regio- and stereochemical outcome of nitrile oxide cycloadditions is influenced by nearly stoichiometric quantities of the cation, whilst catalytic amounts of Mg(II) influence both the reactivity and the stereoselectivity of the nitrone cycloadditions. The results obtained support a reaction mechanism involving the coordination of the Mg(II) to the dicarbonyl fragment of the chiral auxiliary.