3859-65-2

Basic information

• Product Name: 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate
• Synonyms: 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate
• CAS NO: 3859-65-2
• Molecular Formula: C₂₃H₂₉FO₇
• Molecular Weight: 436.47
• Mol File: 3859-65-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate(3859-65-2)
• EPA Substance Registry System: 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate(3859-65-2)

Safety Data

• Hazardous Substances Data: 3859-65-2(Hazardous Substances Data)

Usage

Description

9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate, also known as Triamcinolone 21-Acetate, is a chemical compound derived from the pregnane class of steroids. It is characterized by the presence of a fluorine atom at the 9th position, hydroxyl groups at the 11th, 16th, and 21st positions, and an acetate group at the 21st position. 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate exhibits structural similarities to glucocorticoids, which are known for their anti-inflammatory and immunosuppressive properties.

Uses

Used in Pharmaceutical Industry:
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate is used as an impurity in the synthesis of Triamcinolone, a glucocorticoid with anti-inflammatory and immunosuppressive properties. Triamcinolone is widely used in the treatment of various conditions, including asthma, allergies, and autoimmune diseases, due to its ability to modulate the immune system and reduce inflammation.
Used in Research and Development:
In addition to its role as an impurity in the pharmaceutical industry, 9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate may also be utilized in research and development for the study of steroidal compounds and their potential applications in medicine. Its unique structural features make it an interesting candidate for exploring novel therapeutic approaches and understanding the mechanisms of action of glucocorticoids.

Upstream product

• 3925-42-6 16α-Acetoxy-9α-fluor-11β,17α,21-trihydroxy-pregna-1,4-dien-3,20-dion 
• 124-94-7 triamcinolone 
• 37413-91-5 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 
• 39987-51-4 1,4-pregnane-9α-fluoro-11β,17α,21-triol-3,20-dione 17,21-diacetate 
• 1250-85-7 9α-Fluoro-11β,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate 

Downstream Products

• 124-94-7 triamcinolone 

Relevant articles and documents

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NOVEL PROCESS FOR PREPARATION OF GLUCOCORTICOID STEROIDS

The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group; aryl or heteroaryl group; or R1 and R2 combine to form saturated, unsaturated C3-C6 cyclic or heterocyclic ring; R3 and R4 are same or different and each independently represents H or halogen; R5 is -OH or –OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that may be substituted.