38604-68-1

Basic information

• Product Name: Acetic acid, 2-methyl-2-phenylhydrazide
• CAS NO: 38604-68-1
• Molecular Formula: C9H12N2O
• Molecular Weight: 164.207
• Mol File: 38604-68-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Acetic acid, 2-methyl-2-phenylhydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, 2-methyl-2-phenylhydrazide(38604-68-1)
• EPA Substance Registry System: Acetic acid, 2-methyl-2-phenylhydrazide(38604-68-1)

Safety Data

• Hazardous Substances Data: 38604-68-1(Hazardous Substances Data)

Upstream product

• 7423-14-5 methyl ethyl ketone N-methylphenylhydrazone 
• 108-24-7 acetic anhydride 
• 104-15-4 toluene-4-sulfonic acid 
• 3741-86-4 acetone methylphenylhydrazone 
• 100-63-0 phenylhydrazine 
• 100-61-8 N-methylaniline 
• 1004-12-2 N-deutero-N-methyl-aniline 
• 64-18-6 formic acid 
• 114-83-0 1-acetyl-2-phenylhydrazine 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 625-77-4 N-acetylacetamide 
• 618-40-6 1-Methyl-1-phenylhydrazine 

Downstream Products

• 618-40-6 1-Methyl-1-phenylhydrazine 
• 103134-04-9 N-(N'-methylanilino)ethanimidoyl chloride 
• 1616861-89-2 C₁₈H₁₇BrN₂O₂ 
• 1616861-88-1 2-(2-acetyl-1-methyl-2,3-dihydro-1H-indazol-3-yl)-1-(4-chlorophenyl)-ethanone 
• 1616861-87-0 2-(2-acetyl-1-methyl-2,3-dihydro-1H-indazol-3-yl)-1-p-tolylethanone 
• 1468535-94-5 2-(1-methyl-1H-indazol-3-yl)-1-phenylethanone 
• 1604806-88-3 2-(2-acetyl-1-methyl-2,3-dihydro-1H-indazol-3-yl)-1-phenylethanone 
• 1604806-83-8 benzyl 2-(2-acetyl-1-methyl-2,3-dihydro-1H-indazol-3-yl)acetate 
• 103134-10-7 (E)-N,N-dimethyl-N'-(N''-methylanilino)ethanimidamide 
• 42108-38-3 N-acetyl-N,N'-dimethyl-N'-phenylhydrazine 

Relevant articles and documents

Nitrene-mediated intermolecular N–N coupling for efficient synthesis of hydrazides

N–N linkages are found in many natural compounds and endow fascinating structural and functional properties. In comparison to the myriad methods for the construction of C–N bonds, chemistry for N–N coupling, especially in an intermolecular fashion, remains underdeveloped. Here, we report a nitrene-mediated intermolecular N–N coupling of dioxazolones and arylamines under iridium or iron catalysis. These reactions offer a simple and efficient method for the synthesis of various hydrazides from readily available carboxylic acid and amine precursors. Although the Ir-catalysed conditions usually give higher N–N coupling yield than the Fe-catalysed conditions, the reactions of sterically more demanding dioxazolones derived from α-substituted carboxylic acids work much better under the Fe-catalysed conditions. Mechanistic studies revealed that the nitrogen atom of Ir acyl nitrene intermediates has strong electrophilicity and can undergo nucleophilic attack with arylamines with the assistance of Cl···HN hydrogen bonding to form the N–N bond with high efficiency and chemoselectivity. [Figure not available: see fulltext.].

Rh(III)-catalyzed oxidative coupling of 1,2-disubstituted arylhydrazines and olefins: A new strategy for 2,3-dihydro-1H-indazoles

A rhodium(III)-catalyzed oxidative olefination of 1,2-disubstituted arylhydrazines with alkenes via sp2 C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construct

Synthesis of 2,3-dihydro-1H-indazoles by Rh(iii)-catalyzed C-H cleavage of arylhydrazines

A rhodium-catalyzed efficient method for the synthesis of 2,3-dihydro-1H-indazoles is described. The reaction of arylhydrazines with olefins results in the corresponding 2,3-dihydro 1H-indazoles with exclusive regioselectivity via C-H bond activation. The utility of the methodology is illustrated by a rapid synthesis of 1H-indazoles under mild reaction conditions in half an hour. This journal is the Partner Organisations 2014.