38661-84-6Relevant articles and documents
Coupling of propargylsilanes with Fischer carbene chromium complexes: A new synthesis of conjugated dienes
Patel, Paren P.,Zhu, Yixin,Zhang, Lei,Herndon, James W.
, p. 3379 - 3387 (2004)
The reaction of propargylsilanes with Fischer carbene complexes has been examined. If the silane-containing carbon is secondary the predominant pathway involves formation of conjugated dienes through a 1,2-silicon shift process of the initially formed vin
One-pot synthesis of α,β-unsaturated ketones through sequential alkyne dimerization/hydration reactions using the Hoveyda-Grubbs catalyst
?ztürk, Bengi ?zgün,?ehito?lu, Solmaz Karabulut,A?kun, Mina,Sar?aslan, Begüm,Tunal?, Zeynep
supporting information, p. 16689 - 16695 (2021/09/27)
Herein we report a sequential one-pot alkyne dimerization/hydration protocol for the regioselective synthesis of α,β-unsaturated ketones in quantitative yields. The alkyne dimerization reactions of terminal arylacetylenes proceeded with high regioselectivity in the presence of the Hoveyda-Grubbs 2nd generation catalyst (1 mol%) and tricyclohexylphosphine (4 mol%). The hydration reactions ofin situformed 1-aryl-3-en-1-ynes proceeded very rapidly in the presence of CCl3COOH/p-TsOH·H2O, yielding the corresponding unsaturated ketones within 15 minutes in quantitative yields. Different arylacetylene derivatives were converted to the corresponding α,β-unsaturated ketones in quantitative yields (94-95%) using sequential one-pot alkyne dimerization/hydration reactions.
Palladium-catalyzed synthesis of 2-alkenyl-3-arylindoles via a dual α-arylation strategy: Formal synthesis of the antilipemic drug fluvastatin
Kale, Ajit Prabhakar,Kumar, Gangam Srikanth,Kapur, Manmohan
, p. 10995 - 11002 (2015/11/25)
A new approach has been developed for the synthesis of substituted 2-alkenyl-3-arylindoles. The strategy comprises palladium-catalyzed dual α-arylation of TES-enol ethers of enones as the key step. This methodology results in products with very good yields and the regioselectivity is exclusive. We have also successfully used this dual α-arylation methodology in the formal synthesis of the cholesterol-lowering drug fluvastatin.
Synthesis of highly decorated chiral 2-nitro-cyclohexane carboxylic esters through microwave-assisted organocatalyzed cascade reactions
Massolo, Elisabetta,Benaglia, Maurizio,Parravicini, Davide,Brenna, Davide,Annunziata, Rita
, p. 6639 - 6642 (2015/01/08)
Starting from (E)-β-substituted-β-nitroacrylates and α,β-unsaturated ketones, a stereoselective organocatalyzed one-pot methodology allowed to synthesize highly decorated chiral 2-nitro-cyclohexane carboxylic esters. The reaction is promoted by Cinchona a
