386704-04-7

Basic information

• Product Name: 6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL
• Synonyms: 2-(TRIFLUOROMETHYL)PYRIDINE-5-METHANOL;5-(HYDROXYMETHYL)-2-(TRIFLUOROMETHYL)PYRIDINE;6-TRIFLUOROMETHYL-3-PYRIDINEMETHANOL;6-TRIFLUOROMETHYL-3-PYRIDYLMETHANOL;6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL;RARECHEM AL BD 1231;[6-(trifluoromethyl)pyridin-3-yl]methanol;[6-(trifluoromethyl)-3-pyridinyl]methanol
• CAS NO: 386704-04-7
• Molecular Formula: C₇H₆F₃NO
• Molecular Weight: 177.12
• Product Categories: Alcohols and Derivatives;Heterocycles;Hydroxymethyl's;Pyridines;Heterocyclic Compounds;C7 and C8;Heterocyclic Building Blocks
• Mol File: 386704-04-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 100-102/0.75mm
• Flash Point: 110 °C
• Appearance: /
• Density: 1.363 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.36±0.10(Predicted)
• CAS DataBase Reference: 6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL(386704-04-7)
• EPA Substance Registry System: 6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL(386704-04-7)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-37/38-41-43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 386704-04-7(Hazardous Substances Data)

Usage

Description

6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL is a heterocyclic organic compound characterized by the presence of a trifluoromethyl group attached to the pyridine ring and a hydroxymethyl group at the third position. This unique molecular structure endows it with specific chemical properties and reactivity, making it a versatile building block in the synthesis of various pharmaceuticals and other organic compounds.

Uses

Used in Pharmaceutical Industry:
6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL is used as a key intermediate in the synthesis of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. These inhibitors play a crucial role in regulating the body's response to stress and inflammation, as well as maintaining glucose homeostasis. By targeting 11β-HSD1, these compounds can potentially be used in the treatment of various metabolic disorders, such as type 2 diabetes and obesity.
Used in Chemical Synthesis:
As a heterocyclic organic compound, 6-(TRIFLUOROMETHYL)PYRIDINE-3-METHANOL serves as a valuable building block in the synthesis of a wide range of complex organic molecules. Its unique structure allows for various functional group transformations and reactions, making it a useful starting material for the development of novel pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 231291-22-8 6-trifluoromethylnicotinic acid 
• 221313-10-6 methyl 6-(trifluoromethyl)pyridine-3-carboxylate 
• 386704-12-7 6-(trifluoromethyl)pyridine-3-carbaldehyde 

Downstream Products

• 913839-73-3 2-[6-(trifluoromethyl)-3-pyridyl]acetic acid 
• 386704-12-7 6-(trifluoromethyl)pyridine-3-carbaldehyde 
• 1108556-21-3 5-(azidomethyl)-2-(trifluoromethyl)pyridine 
• 765298-04-2 2-(6-(trifluoromethyl)pyridin-3-yl)acetonitrile 
• 1372175-39-7 (S)-4-chloro-N-(1-phenylpropyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)benzenesulfonamide 
• 386715-33-9 3-chloromethyl-6-(trifluoromethyl)pyridine 
• 108274-33-5 5-(bromomethyl)-2-(trifluoromethyl)pyridine 
• 2107987-82-4 O-ethyl S-((6-(trifluoromethyl)pyridin-3-yl)methyl)carbonodithioate 

Relevant articles and documents

Sulfoxaflor hapten, preparation method thereof, antigen, antibody and application thereof

The invention provides a sulfoxaflor hapten, a method for preparing the hapten, a sulfoxaflor antigen obtained by coupling the hapten with carrier protein, a sulfoxaflor antibody obtained by immunizing animals with the sulfoxaflor antigen, and applications of the sulfoxaflor hapten, the antigen and the antibody in immunological detection. The invention further discloses a sulfoxaflor colloidal gold chromatography detection device prepared from the sulfoxaflor hapten and a method for detecting sulfoxaflor in a sample by using the sulfoxaflor colloidal gold chromatography detection device. According to the preparation method provided by the invention, used chemical reagents are easy to obtain, the operation process is simple, the reaction yield is relatively high, and the detection cost is relatively low. The detection device provided by the invention can rapidly and accurately detect the residual content of sulfoxaflor in vegetables or fruits, and can meet the requirements of supervision departments and detection organizations for on-site supervision and law enforcement. The detection method provided by the invention has the advantages of high sensitivity, strong specificity, low cost, simple operation, short detection time and long shelf life.

IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK

The invention is directed to substituted imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y1, Y2 and Z are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes, as Alzheimer's disease, neuropathic pain, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, Parkinson disease, diabetes, metabolic syndrome, metabolic disorders, Huntington's disease, Creutzfeldt-Jakob Disease, fatal familial insomnia, Gerstmann-Str?ussler-Scheinker syndrome, and related prion diseases, amyotrophic lateral sclerosis, progressive supranuclear palsy, myocardial infarction, cardiovascular disease, inflammation, organ fibrosis, chronic and acute diseases of the liver, fatty liver disease, liver steatosis, liver fibrosis, chronic and acute diseases of the lung, lung fibrosis, chronic and acute diseases of the kidney, kidney fibrosis, chronic traumatic encephalopathy (CTE), neurodegeneration, dementias, frontotemporal dementias, tauopathies, Pick's disease, Neimann-Pick's disease, amyloidosis, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

NITROGEN-CONTAINING HETEROCYCLIC ALKENYL COMPOUND, ORGANIC SEMICONDUCTOR MATERIAL AND ORGANIC SEMICONDUCTOR DEVICE

PROBLEM TO BE SOLVED: To provide a compound that is high in charge transfer and atmosphere stability and is suitable for an organic semiconductor material, provide an organic semiconductor material comprising the compound, and provide an organic semiconductor element comprising the organic semiconductor material. SOLUTION: The present invention provides a compound represented by formula (1), specifically a compound represented by formula (2) (Ar1 is an unsaturated cyclic hydrocarbon group or the like; Ar2 is an unsaturated heterocyclic group containing nitrogen with an unshared electron pair, or the like; B is -CH=CH- or -C≡C-; X11-X13 independently represent C-R or N; at least one of X12 and X13 is N). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2018,JPOandINPIT