386715-35-1Relevant articles and documents
Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase
Ruf, Sven,Hallur, Mahanandeesha Siddappa,Anchan, Nisha K.,Swamy, Indu N.,Murugesan, Karthikai Raj,Sarkar, Sayantani,Narasimhulu, Lokesh Kananti,Putta, V.P. Rama Kishore,Shaik, Shama,Chandrasekar, Devaraj Venkatapura,Mane, Vishal Subhash,Kadnur, Sanjay Venkatachalapathi,Suresh, Juluri,Bhamidipati, Ravi Kanth,Singh, Manvi,Burri, Raghunadha Reddy,Kristam, Rajendra,Schreuder, Herman,Czech, Joerg,Rudolph, Christine,Marker, Alexander,Langer, Thomas,Mullangi, Ramesh,Yura, Takeshi,Gosu, Ramachandraiah,Kannt, Aimo,Dhakshinamoorthy, Saravanakumar,Rajagopal, Sridharan
supporting information, p. 922 - 925 (2018/02/14)
Nicotinamide N-methyltransferase (NNMT) has been linked to obesity and diabetes. We have identified a novel nicotinamide (NA) analog, compound 12 that inhibited NNMT enzymatic activity and reduced the formation of 1-methyl-nicotinamide (MNA), the primary metabolite of NA by ～80% at 2 h when dosed in mice orally at 50 mg/kg.
Having a three-nitrogen azoles ring structure of immunosuppressant drug synthesis method
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Paragraph 0038; 0039; 0040, (2018/04/01)
The invention discloses a has three nitrogen azoles ring structure of immunosuppressant drug synthesis method, which belongs to the technical field of medical synthesis. Technical proposal of the invention points are: having a three-nitrogen azoles ring structure immunosuppressive drug, has the following structure: The invention also discloses the has three nitrogen azoles ring structure of immunosuppressant drug preparation method. The invention through a new synthesis method with three nitrogen azoles ring structure the immunosuppressant drug, the reaction process is simple and easy operation, the raw material is cheap, relatively high reaction efficiency and good repeatability, the immunosuppressant drug active effect is obvious.
