38695-92-0

Basic information

• Product Name: 1H-pyrazol-5-ol, 3-methyl-1-(2-pyridinyl)-
• Synonyms: 1H-pyrazol-5-ol, 3-methyl-1-(2-pyridinyl)-;3-methyl-1-pyridin-2-yl-1H-pyrazol-5-ol;UYJSZZFTYQECBI-UHFFFAOYSA-N
• CAS NO: 38695-92-0
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.18726
• Mol File: 38695-92-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-pyrazol-5-ol, 3-methyl-1-(2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-pyrazol-5-ol, 3-methyl-1-(2-pyridinyl)-(38695-92-0)
• EPA Substance Registry System: 1H-pyrazol-5-ol, 3-methyl-1-(2-pyridinyl)-(38695-92-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 38695-92-0(Hazardous Substances Data)

Usage

General Description

1H-pyrazol-5-ol, 3-methyl-1-(2-pyridinyl)- is a chemical compound with the molecular formula C8H8N2O. It is a pyrazole derivative with a methyl and a pyridinyl group attached to the 3rd and 1st carbon atoms, respectively. 1H-pyrazol-5-ol, 3-methyl-1-(2-pyridinyl)- is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules. It exhibits potential medicinal properties and is researched for its anti-inflammatory and analgesic effects. Additionally, it is utilized in various research and development processes for the creation of new pharmaceutical drugs and compounds.

Upstream product

• 4930-98-7 pyrid-2-ylhydrazine 
• 141-97-9 ethyl acetoacetate 
• 1207678-75-8 2-(5-isopropoxy-3-methyl-1H-pyrazol-1-yl)pyridine 
• 109-09-1 2-chloropyridine 
• 123-54-6 acetylacetone 

Downstream Products

• 1334782-08-9 (4Z)-4-[amino(phenyl)methylene]-5-methyl-2-(2-pyridinyl)-2,4-dihydro-3H-pyrazol-3-one 
• 1334782-03-4 [5-hydroxy-3-methyl-1-(2-pyridinyl)-1H-pyrazol-4-yl](phenyl)methanone 
• 153231-88-0 4,4'-(phenylmethylene)bis[3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-ol] 
• 1334782-05-6 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-yl benzoate 
• 1354790-50-3 5-methyl-3-oxo-2-(pyridin-2-yl)-N-(3-(trifluoromethyl)phenyl)-2,3-dihydro-1H-pyrazole-4-carboxamide 

Relevant articles and documents

4-Substituted quinoline derivatives and preparation methods and applications thereof

The present invention provides a 4-substituted quinoline derivative and preparation method and application thereof, in particular, the present invention relates to a compound shown in formula (I), a method for preparing a compound shown in formula (I), an

Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation

Solute carrier proteins (SLCs) control fluxes of ions and molecules across biological membranes and represent an emerging class of drug targets. SLC11A2 (hDMT1) mediates intestinal iron uptake and its inhibition might be used to treat iron overload diseases such as hereditary hemochromatosis. Here we report a micromolar (IC50 = 1.1 μM) pyrazolyl-pyrimidone inhibitor of radiolabeled iron uptake in hDMT1 overexpressing HEK293 cells acting by a non-competitive mechanism, which however does not affect the electrophysiological properties of the transporter. Isothermal titration calorimetry, competition with calcein, induced precipitation of radioactive iron and cross inhibition of the unrelated iron transporter SLC39A8 (hZIP8) indicate that inhibition is mediated by metal chelation. Mapping the chemical space of thousands of pyrazolo-pyrimidones and similar 2,2′-diazabiaryls in ChEMBL suggests that their reported activities might partly reflect metal chelation. Such metal chelating groups are not listed in pan-assay interference compounds (PAINS) but should be checked when addressing SLCs.

N-arylation of 3-alkoxypyrazoles, the case of the pyridines

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